The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 38, 561-571, Copyright, 1923, by The Rockefeller Institute for Medical Research New York

ARTICLE

ON THE ANTIGENIC PROPERTIES OF HEMOGLOBIN

M. Heidelberger Ph.D.1 and K. Landsteiner M.D.1

1 From the Hospital and the Laboratories of The Rockefeller Institute for Medical Research.

Sera produced by immunization with crystalline oxyhemoglobin react species-specifically with hemoglobin solutions.

Evidence is presented that in this reaction the hemoglobin itself is the active substance.

Conversion of oxyhemoglobin into methemoglobin, carbon-monoxy hemoglobin, or cyanhemoglobin does not alter the response to the precipitating immune serum.

Not only the hemoglobin of homologous species, but also that of other species causes inhibition in greater or less degree of the precipitin reaction.

 Submitted on June 17, 1923


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