The Journal of Experimental Medicine
Torrey Pines Biolabs
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The Journal of Experimental Medicine, Vol 38, 149-161, Copyright, 1923, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON PNEUMOCOCCUS IMMUNITY : II. ACTIVE IMMUNIZATION OF MONKEYS AGAINST PNEUMOCOCCUS TYPES II, III, AND IV PNEUMONIA WITH THE HOMOLOGOUS PNEUMOCOCCUS VACCINE.



Russell L. Cecil M.D.1 and Gustav I. Steffen 1

1 From the Hygienic Laboratory of the United States Public Health Service and the Second Medical (Cornell) Division and Pathological Laboratory of Bellevue Hospital, New York.

1. Three subcutaneous injections of Pneumococcus Type II vaccine confer on monkeys a complete immunity against experimental Pneumococcus Type II pneumonia. A similar protection can be bestowed on monkeys against Pneumonococcus Type IV pneumonia by three subcutaneous injections of a vaccine prepared from the same strain of pneumococcus.

2. The subcutaneous injection of monkeys with three doses of Pneumococcus Type III vaccine confers a complete immunity against this type in only 50 per cent of cases (four out of eight monkeys vaccinated).

3. In spite of the immunity induced in monkeys by three subcutaneous injections of Pneumococcus Types II, III, and IV vaccine, specific protective bodies against the homologous types are not demonstrable in their serums when the vaccine is so administered.

 Submitted on March 27, 1923


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