The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 37, 767-779, Copyright, 1923, by The Rockefeller Institute for Medical Research New York

ARTICLE

SEPARATION OF THE TOXINS OF BACILLUS DYSENTERIÆ SHIGA

James E. McCartney M.D.1 and Peter K. Olitsky M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research.

By the suppression, through anaerobiosis, of the exotoxin-producing activity of Bacillus dysenteriæ Shiga a pure endotoxin is produced directly from the culture. The duality of the poison of Shiga bacillus is further substantiated by studies on the diffusion of exotoxin, or neurotoxin, and endotoxin, or enterotoxin, by means of collodion sacs, implanted intraabdominally in rabbits or placed in vitro.

Submitted on January 16, 1923


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