The Journal of Experimental Medicine
Track the topics, authors and articles important to you
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 1269K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swift, H. F.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Swift, H. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 36, 735-760, Copyright, 1922, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE ACTION OF SODIUM SALICYLATE UPON THE FORMATION OF IMMUNE BODIES

Homer F. Swift M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research.

1. Rabbits treated with sodium salicylate in daily doses of from 0.16 to 0.2 gm. per kilo of body weight and at the same time immunized with intravenous injections of Streptococcus viridans, both living and in the form of vaccines, and also with washed sheep red blood cells, showed diminished complement-fixing antibodies, agglutinins, and hemolysins when compared with controls similarly immunized.

2. If the antigens were treated with sodium salicylate in vitro and subsequently injected intravenously into rabbits, the animals usually showed lower antibody curves than did rabbits that received the untreated antigen intravenously and sodium salicylate by stomach tube.

3. The beneficial effect of sodium salicylate in rheumatic fever patients probably cannot be attributed to an increased production of circulating immune bodies against the infectious agent. This is, however, no contraindication to the administration of salicylates to patients suffering from infectious diseases.

 Submitted on July 6, 1922


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS