The Journal of Experimental Medicine
PBL InterferonSource
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 718K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hagan, W. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Hagan, W. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 36, 711-725, Copyright, 1922, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE VALUE OF HEAT-KILLED CULTURES FOR THE PREVENTION OF THE BACILLUS ABORTUS INOCULATION DISEASE OF GUINEA PIGS

William A. Hagan D.V.M.1

1 From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.

From the data presented it seems permissible to draw the following conclusions.

1. Guinea pigs cannot be rendered immune to the Bacillus abortus inoculation disease by treatment with heat-killed cultures of this organism. This agrees with the work of Ascoli, and with the general conclusions of many that dead cultures confer very little or no immunity to infectious abortion in cattle.

2. The progress of the disease can be delayed appreciably by such treatment. This is supported by the following observations: (a) the loss in body weight due to the disease is delayed; (b) the development of splenic enlargement is partially inhibited or delayed; (c) the development of renal lesions is delayed or prevented; and (d) the rapidity of multiplication of Bacillus abortus in the splenic pulp is reduced.

 Submitted on July 6, 1922


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS