The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 36, 291-308, Copyright, 1922, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RELATION BETWEEN THE ACCUMULATION OF GLOBULINS AND THE APPEARANCE OF AGGLUTININS IN THE BLOOD OF NEW-BORN CALVES

Marion L. Orcutt 1 and Paul E. Howe Ph.D.1

1 From the Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N.J.

A comparison of the appearance of the agglutinins for Bacillus abortus in the blood of new-born calves with the first appearance of globulins in the same blood following the ingestion of colostrum indicates that the agglutinins are associated with the globulins. These observations are supported by the removal of the agglutinins from serum or colostrum with concentrations of sodium sulfate which precipitate globulins present in the blood of calves which have ingested colostrum, but which are not present at birth.

Neither the association of immune bodies with globulins nor the direct absorption of protein by new-born animals is a new fact. The evidence presented is of particular value, however, in associating the appearance of certain protein fractions in the blood of the new-born animal with the simultaneous absorption of agglutinins.

 Submitted on April 9, 1922


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