The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 34, 349-363, Copyright, 1921, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE DIASTATIC ACTIVITY OF THE BLOOD IN EXPERIMENTAL HYPERGLYCEMIA

Howard T. Karsner M.D.1, Herbert L. Koeckert M.D.1, and Spencer A. Wahl M.D.1

1 From the Department of Pathology of the School of Medicine, Western Reserve University, Cleveland.

1. The diastatic activity of the blood is not materially changed by the subcutaneous injection of phlorhizin, uranyl nitrate, or adrenalin.

2. The diastatic activity of the blood is not affected by puncture of the floor of the fourth ventricle.

3. The diastatic activity of the blood is definitely increased by subcutaneous injections of morphia when a marked hyperglycemia is produced. The same phenomenon appears in asphyxia.

4. Complete pancreatectomy in dogs produces an increase in the diastatic activity of the blood.

5. The diastatic activity of the blood is not altered by the diet.

6. Ether anesthesia, alone, produces a very slight tendency to increase in the diastatic activity of the blood.

7. Repeated periodic small hemorrhages (4.5 cc.) produce no change in the diastatic activity of the blood until a definite color anemia results, when a slight tendency toward increase occurs simultaneously with the rise in blood sugar.

8. The diastatic activity of the blood is not proportional to the concentration of the sugar in the blood.

 Submitted on May 6, 1921


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