The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 34, 245-258, Copyright, 1921, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON PNEUMOCOCCUS IMMUNITY : I. ACTIVE IMMUNIZATION OF MONKEYS AGAINST PNEUMOCOCCUS TYPE I PNEUMONIA WITH PNEUMOCOCCUS TYPE I VACCINE.



Russell L. Cecil M.D.1 and Gustav I. Steffen 1

1 From the Hygienic Laboratory of the United States Public Health Service, Washington.

1. The subcutaneous inoculation of monkeys with three large doses of Pneumococcus Type I vaccine confers on them a complete immunity against experimental Pneumococcus Type I pneumonia.

2. The intravenous inoculation of small doses of Pneumococcus Type I vaccine also confers complete immunity against the homologous type of pneumonia.

3. Specific protective bodies may or may not be present in the serum of monkeys vaccinated against Pneumococcus Type I. There appears to be no intimate relation between active immunity against pneumonia and the presence or absence of protective substances in the serum of the vaccinated animal.

 Submitted on March 31, 1921


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