The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online April 28, 2008
doi:10.1084/jem.20070850
The Journal of Experimental Medicine, Vol. 205, No. 5, 1099-1108
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Smith-Bouvier et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Smith-Bouvier, D. L.
Right arrow Articles by Voskuhl, R. R.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Smith-Bouvier, D. L.
Right arrow Articles by Voskuhl, R. R.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Autoimmune Diseases
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ARTICLE

 A role for sex chromosome complement in the female bias in autoimmune disease

Deborah L. Smith-Bouvier1, Anagha A. Divekar3, Manda Sasidhar1, Sienmi Du1, Seema K. Tiwari-Woodruff1, Jennifer K. King3, Arthur P. Arnold2, Ram Raj Singh3,4, and Rhonda R. Voskuhl1

1 Department of Neurology, 2 Department of Physiological Science, 3 Department of Medicine, Division of Rheumatology, and 4 Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095

CORRESPONDENCE Rhonda R. Voskuhl: rvoskuhl{at}ucla.edu OR Ram R. Singh: RRSingh{at}mednet.ucla.edu

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.

Abbreviations used: CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; LNC, LN cell; MOG, myelin oligodendrocyte glycoprotein; PLP, proteolipid protein.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS