The Journal of Experimental Medicine
CSHL Meetings & Courses
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online March 17, 2008
doi:10.1084/jem.20080066
The Journal of Experimental Medicine, Vol. 205, No. 4, 747-750
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Williams et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Williams, A.
Right arrow Articles by Flavell, R. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williams, A.
Right arrow Articles by Flavell, R. A.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

COMMENTARY

 The role of CTCF in regulating nuclear organization

Adam Williams and Richard A. Flavell

A.W and R.A.F. are at the Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520

CORRESPONDENCE R.A.F.: richard.flavell{at}yale.edu


ABSTRACT
The spatial organization of the genome is thought to play an important part in the coordination of gene regulation. New techniques have been used to identify specific long-range interactions between distal DNA sequences, revealing an ever-increasing complexity to nuclear organization. CCCTC-binding factor (CTCF) is a versatile zinc finger protein with diverse regulatory functions. New data now help define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and highlight CTCF as an important factor in determining the three-dimensional structure of the genome.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions
Parimal Majumder, Jorge A. Gomez, Brian P. Chadwick, and Jeremy M. Boss
J. Exp. Med. 2008 205: 785-798. [Abstract] [Full Text] [PDF]





  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS