The Journal of Experimental Medicine
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Published online February 11, 2008
doi:10.1084/jem.20080136
The Journal of Experimental Medicine, Vol. 205, No. 2, 267-270
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Dougan et al.
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COMMENTARY

 Inciting inflammation: the RAGE about tumor promotion

Michael Dougan and Glenn Dranoff

M. Dougan and G. Dranoff are at Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

CORRESPONDENCE G.D.: glenn_dranoff{at}dfci.harvard.edu


ABSTRACT
Mechanisms of innate and adaptive immunity play a pivotal role in the development of cancer. Chronic inflammation can drive tumor development, but antitumor immunity can also restrict or even prevent tumor growth. New data show that feed-forward signals downstream of the receptor for advanced glycation end-products (RAGE) can fuel chronic inflammation, creating a microenvironment that is ideal for tumor formation.


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J. Exp. Med. 2008 205: 275-285. [Abstract] [Full Text] [PDF]





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