The Journal of Experimental Medicine
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Published online July 23, 2007
doi:10.1084/jem.20062373
The Journal of Experimental Medicine, Vol. 204, No. 8, 1923-1933
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Sapoznikov et al.
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ARTICLE

 Organ-dependent in vivo priming of naive CD4+,but not CD8+,T cells by plasmacytoid dendritic cells

Anita Sapoznikov1, Jens A.A. Fischer2, Tami Zaft1, Rita Krauthgamer1, Andrzej Dzionek2, and Steffen Jung1

1 Department of Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel
2 Miltenyi Biotec GmbH, 51429 Bergisch Gladbach, Germany

CORRESPONDENCE Steffen Jung: s.jung{at}weizmann.ac.il

Plasmacytoid dendritic cells (PDCs) play a pivotal role as cytokine-secreting accessory cells in the antimicrobial immune defense. In contrast, the capacity of PDCs to act as antigen-presenting cells in naive T cell priming remains unclear. By studying T cell responses in mice that lack conventional DCs (cDCs), and by the use of a PDC-specific antigen-targeting strategy, we show that PDCs can initiate productive naive CD4+ T cell responses in lymph nodes, but not in the spleen. PDC-triggered CD4+ T cell responses differed from cDC-driven responses in that they were not associated with concomitant CD8+ T cell priming. Our results establish PDCs as a bona fide DC subset that initiates unique CD4+ Th cell–dominated primary immune responses.

Abbreviations used: cDC, conventional DC; DTR, diphtheria toxin receptor; DTx, diphtheria toxin; HEV, high endothelial venule; IPC, IFN-producing cell; LC, Langerhan cell; PDC, plasmacytoid DC; TLR, Toll-like receptor.


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