The Journal of Experimental Medicine
R&D Systems
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online July 30, 2007
doi:10.1084/jem.20070740
The Journal of Experimental Medicine, Vol. 204, No. 8, 1787-1801
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Cho et al.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 2714K)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cho, J.-H.
Right arrow Articles by Sprent, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cho, J.-H.
Right arrow Articles by Sprent, J.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ARTICLE

 An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2

Jae-Ho Cho1,2, Onur Boyman1,3, Hee-Ok Kim1,2, Bumsuk Hahm1, Mark P. Rubinstein1, Chris Ramsey1, David M. Kim1, Charles D. Surh1, and Jonathan Sprent2

1 Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
2 Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
3 Division of Immunology and Allergy, University Hospital of Lausanne, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland

CORRESPONDENCE Jonathan Sprent: j.sprent{at}garvan.org.au

In conditions of T lymphopenia, interleukin (IL) 7 levels rise and, via T cell receptor for antigen–self–major histocompatibility complex (MHC) interaction, induce residual naive T cells to proliferate. This pattern of lymphopenia-induced "homeostatic" proliferation is typically quite slow and causes a gradual increase in total T cell numbers and differentiation into cells with features of memory cells. In contrast, we describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo. In this situation, CD8+ T cells undergo massive expansion and rapid differentiation into effector cells, thus closely resembling the T cell response to foreign antigens. However, the responses induced by IL-2/IL-15 are not seen in MHC-deficient hosts, implying that the responses are driven by self-ligands. Hence, homeostatic proliferation of naive T cells can be either slow or fast, with the quality of the response to self being dictated by the particular cytokine (IL-7 vs. IL-2/IL-15) concerned. The relevance of the data to the gradual transition of naive T cells into memory-phenotype (MP) cells with age is discussed.

Abbreviations used: APC, allophycocyanin; {gamma}c, common {gamma} chain; MP, memory phenotype; MHC-I–/–, Kb–/– Db–/– ß2M–/–; SIYRp, SIYR peptide; Tg, transgenic.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS