The Journal of Experimental Medicine
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Published online May 7, 2007
doi:10.1084/jem.2045fta
The Journal of Experimental Medicine, Vol. 204, No. 5, 969-
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Bashyam
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FROM THE ARCHIVE

 Interleukin-12: A master regulator

Hema Bashyam, JEM News Editor

hbashyam{at}rockefeller.edu


ABSTRACT
Early resistance to pathogens requires a swift response from NK cells. In 1989, Giorgio Trinchieri identified an NK growth factor and activator, later called interleukin-12 (IL-12). This discovery helped reveal the regulatory link between innate and adaptive immunity.


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