The Journal of Experimental Medicine
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Published online February 5, 2007
doi:10.1084/jem.20061886
The Journal of Experimental Medicine, Vol. 204, No. 2, 285-297
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Anderson et al.
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ARTICLE

 CD4+CD25–Foxp3– Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis

Charles F. Anderson1, Mohammed Oukka2, Vijay J. Kuchroo2, and David Sacks1

1 Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892
2 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115

CORRESPONDENCE David Sacks: dsacks{at}niaid.nih.gov

Nonhealing forms of leishmaniasis in humans are commonly associated with elevated levels of the deactivating cytokine IL-10, and in the mouse, normally chronic infections can be cleared in the absence of IL-10. Using a Leishmania major strain that produces nonhealing dermal lesions in a T helper type 1 (Th1) cell–polarized setting, we have analyzed the cellular sources of IL-10 and their relative contribution to immune suppression. IL-10 was produced by innate cells, as well as CD4+CD25+Foxp3+ and CD4+CD25–Foxp3– T cells in the chronic lesion. Nonetheless, only IL-10 production by antigen-specific CD4+CD25–Foxp3– T cells, the majority of which also produced IFN-{gamma}, was necessary for suppression of acquired immunity in Rag–/– reconstituted mice. Surprisingly, Rag–/– mice reconstituted with naive CD4+ T cells depleted of natural T regulatory cells developed more severe infections, associated with elevated levels of IL-10 and, especially, Th2 cytokines in the site. The data demonstrate that IL-10–producing Th1 cells, activated early in a strong inflammatory setting as a mechanism of feedback control, are the principal mediators of T cell–derived IL-10–dependent immune suppression in a chronic intracellular infection.

Abbreviation used: BMDC, bone marrow–derived DC.


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