Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bursch, L. S. Articles by Hogquist, K. A. Search for Related Content PubMed PubMed Citation Articles by Bursch, L. S. Articles by Hogquist, K. A. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Nucleotide Protein UniGene Related Collections Related Article Social Bookmarking                      What's this?

¹ Department of Laboratory Medicine and Pathology, ² Department of Dermatology, and ³ Center for Immunology, University of Minnesota, Minneapolis, MN 55455
⁴ Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Université de la Méditerranée Parc Scientifique et Technologique de Luminy, Case 906, 13288 Marseille, Cedex 09, France

CORRESPONDENCE Kristin A. Hogquist: hogqu001{at}umn.edu

Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses. While comparing these models, we discovered a novel population of LCs that resides in the dermis and does not represent migrating epidermal LCs, as previously thought. Unlike epidermal LCs, dermal Langerin⁺ dendritic cells (DCs) were radiosensitive and displayed a distinct cell surface phenotype. Dermal Langerin⁺ DCs migrate from the skin to the LNs after inflammation and in the steady state, and represent the majority of Langerin⁺ DCs in skin draining LNs. Both epidermal and dermal Langerin⁺ DCs were depleted by treatment with diphtheria toxin in Lang-DTREGFP knock-in mice. In contrast, transgenic hLang-DTA mice lack epidermal LCs, but have normal numbers of dermal Langerin⁺ DCs. CHS responses were abrogated upon depletion of both epidermal and dermal LCs, but were unaffected in the absence of only epidermal LCs. This suggests that dermal LCs can mediate CHS and provides an explanation for previous differences observed in the two-model systems.

A. Kissenpfennig's present address is Infection and Immunity Group, Centre for Cancer Research and Cell Biology, School of Biomedical Sciences, Queens University, Belfast, Northern Ireland.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Skin DCs go deeper

Richard Robinson
J. Exp. Med. 2007 204: 3054. [Full Text] [PDF]

This article has been cited by other articles:

• Jaensson, E., Uronen-Hansson, H., Pabst, O., Eksteen, B., Tian, J., Coombes, J. L., Berg, P.-L., Davidsson, T., Powrie, F., Johansson-Lindbom, B., Agace, W. W. (2008). Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J. Exp. Med. 205: 2139-2149 [Abstract] [Full Text]  
• Pradhan, S., Kim, H. K., Thrash, C. J., Cox, M. A., Mantena, S. K., Wu, J.-H., Athar, M., Katiyar, S. K., Elmets, C. A., Timares, L. (2008). A Critical Role for the Proapoptotic Protein Bid in Ultraviolet-Induced Immune Suppression and Cutaneous Apoptosis. J. Immunol. 181: 3077-3088 [Abstract] [Full Text]  
• Shklovskaya, E., Roediger, B., Fazekas de St. Groth, B. (2008). Epidermal and Dermal Dendritic Cells Display Differential Activation and Migratory Behavior While Sharing the Ability to Stimulate CD4+ T Cell Proliferation In Vivo. J. Immunol. 181: 418-430 [Abstract] [Full Text]  
• Chang, S.-Y., Cha, H.-R., Igarashi, O., Rennert, P. D., Kissenpfennig, A., Malissen, B., Nanno, M., Kiyono, H., Kweon, M.-N. (2008). Cutting Edge: Langerin+ Dendritic Cells in the Mesenteric Lymph Node Set the Stage for Skin and Gut Immune System Cross-Talk. J. Immunol. 180: 4361-4365 [Abstract] [Full Text]  
• Wang, L., Bursch, L. S., Kissenpfennig, A., Malissen, B., Jameson, S. C., Hogquist, K. A. (2008). Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions. J. Immunol. 180: 4722-4727 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS