Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ginhoux, F. Articles by Merad, M. Search for Related Content PubMed PubMed Citation Articles by Ginhoux, F. Articles by Merad, M. Related Collections Related Article Social Bookmarking                      What's this?

¹ Department of Gene and Cell Medicine and ² Department of Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029
³ Unidad de Imunologia de Transplantes, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Madrid, Spain
⁴ Centre d'Immunologie de Marseille-Luminy, Institut National de la Santé et de la Recherche Médicale U631, Centre National de la Recherche Scientifique UMR6102, Université de la Méditerrannée, 13288 Marseille Cedex 9, France

CORRESPONDENCE Miriam Merad: Miriam.Merad{at}mssm.edu

Langerin is a C-type lectin receptor that recognizes glycosylated patterns on pathogens. Langerin is used to identify human and mouse epidermal Langerhans cells (LCs), as well as migratory LCs in the dermis and the skin draining lymph nodes (DLNs). Using a mouse model that allows conditional ablation of langerin⁺ cells in vivo, together with congenic bone marrow chimeras and parabiotic mice as tools to differentiate LC- and blood-derived dendritic cells (DCs), we have revisited the origin of langerin⁺ DCs in the skin DLNs. Our results show that in contrast to the current view, langerin⁺CD8^– DCs in the skin DLNs do not derive exclusively from migratory LCs, but also include blood-borne langerin⁺ DCs that transit through the dermis before reaching the DLN. The recruitment of circulating langerin⁺ DCs to the skin is dependent on endothelial selectins and CCR2, whereas their recruitment to the skin DLNs requires CCR7 and is independent of CD62L. We also show that circulating langerin⁺ DCs patrol the dermis in the steady state and migrate to the skin DLNs charged with skin antigens. We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies.

A. Kissenpfennig's present address is Infection and Immunity Group, Center for Cancer Research and Cell Biology, School of Biomedical Sciences, Queen's University, Belfast, Northern Ireland.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Related Article

Skin DCs go deeper

Richard Robinson
J. Exp. Med. 2007 204: 3054. [Full Text] [PDF]

This article has been cited by other articles:

• Shklovskaya, E., Roediger, B., Fazekas de St. Groth, B. (2008). Epidermal and Dermal Dendritic Cells Display Differential Activation and Migratory Behavior While Sharing the Ability to Stimulate CD4+ T Cell Proliferation In Vivo. J. Immunol. 181: 418-430 [Abstract] [Full Text]  
• Chang, S.-Y., Cha, H.-R., Igarashi, O., Rennert, P. D., Kissenpfennig, A., Malissen, B., Nanno, M., Kiyono, H., Kweon, M.-N. (2008). Cutting Edge: Langerin+ Dendritic Cells in the Mesenteric Lymph Node Set the Stage for Skin and Gut Immune System Cross-Talk. J. Immunol. 180: 4361-4365 [Abstract] [Full Text]  
• Poulin, L. F., Henri, S., de Bovis, B., Devilard, E., Kissenpfennig, A., Malissen, B. (2007). The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J. Exp. Med. 204: 3119-3131 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS