The Journal of Experimental Medicine
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Published online December 10, 2007
doi:10.1084/jem.20071003
The Journal of Experimental Medicine, Vol. 204, No. 13, 3085-3093
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Six et al.
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BRIEF DEFINITIVE REPORT

 A human postnatal lymphoid progenitor capable of circulating and seeding the thymus

Emmanuelle M. Six1,2, Delphine Bonhomme1,2, Marta Monteiro2,3, Kheira Beldjord2,4,7, Monika Jurkowska4, Corinne Cordier-Garcia2, Alexandrine Garrigue1,2,5, Liliane Dal Cortivo5, Benedita Rocha2,3, Alain Fischer1,2,6, Marina Cavazzana-Calvo1,2,5, and Isabelle André-Schmutz1,2

1 Institut National de la Santé et de la Recherche Médicale (INSERM), U768, 75015 Paris, France
2 Faculté de Médecine René Descartes, Institut Federatif de Recherche 94, Université Paris-Descartes, 75015 Paris, France
3 INSERM, U591, 75015 Paris, France
4 Laboratoire d'Hématologie, 5 Département de Biothérapie, and 6 Service d'Immunologie et d'Hématologie Pédiatrique, Hopital Necker-Enfants Malades, Assistance Publique–Hôpitaux de Paris, 75015 Paris, France
7 INSERM, EMI0210, 75015 Paris, France

CORRESPONDENCE Isabelle André-Schmutz: andre-schmutz{at}necker.fr

Identification of a thymus-seeding progenitor originating from human bone marrow (BM) constitutes a key milestone in understanding the mechanisms of T cell development and provides new potential for correcting T cell deficiencies. We report the characterization of a novel lymphoid-restricted subset, which is part of the lineage-negative CD34+CD10+ progenitor population and which is distinct from B cell–committed precursors (in view of the absence of CD24 expression). We demonstrate that these Lin–CD34+CD10+CD24– progenitors have a very low myeloid potential but can generate B, T, and natural killer lymphocytes and coexpress recombination activating gene 1, terminal deoxynucleotide transferase, PAX5, interleukin 7 receptor {alpha}, and CD3{epsilon}. These progenitors are present in the cord blood and in the BM but can also be found in the blood throughout life. Moreover, they belong to the most immature thymocyte population. Collectively, these findings unravel the existence of a postnatal lymphoid-polarized population that is capable of migrating from the BM to the thymus.

E.M. Six and D. Bonhomme contributed equally to this work.

D. Bonhomme's present address is Cythéris, 92130 Issy-les-Moulineaux, France.


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