The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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Published online September 24, 2007
doi:10.1084/jem.20062535
The Journal of Experimental Medicine, Vol. 204, No. 10, 2253-2257
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Iliev et al.
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COMMENTARY

 The yin and yang of intestinal epithelial cells in controlling dendritic cell function

Iliyan D. Iliev, Gianluca Matteoli, and Maria Rescigno

CORRESPONDENCE M.R.: maria.rescigno{at}ifom-ieo-campus.it


ABSTRACT
Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.

I.D. Iliev, G. Matteoli, and M. Rescigno are at Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.


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