The Journal of Experimental Medicine
Randox
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Published online September 24, 2007
doi:10.1084/jem.20071737
The Journal of Experimental Medicine, Vol. 204, No. 10, 2249-2252
The Rockefeller University Press, 0022-1007 $30.00
© 2007 Ehrenstein et al.
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COMMENTARY

 If the treatment works, do we need to know why?: the promise of immunotherapy for experimental medicine

Michael R. Ehrenstein and Claudia Mauri

CORRESPONDENCE M.R.E.: m.ehrenstein{at}ucl.ac.uk


ABSTRACT
There has been much fanfare, and rightly so, heralding a revolution in the treatment of autoimmune disease using biologic agents—antibodies or other molecules that specifically target known mediators of disease. But not all patients respond to even the most successful biologic agent, which may provide clues about alternate disease mechanisms. Studies aimed at understanding the mechanism of action of biologic agents will yield significant benefits for experimental medicine.

M.R.E. and C.M. are at Department of Medicine, University College London, London W1T 4JF, UK.


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