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¹ Trudeau Institute, Inc., Saranac Lake, NY 12983
² Genentech Inc., South San Francisco, CA 94080

CORRESPONDENCE Andrea M. Cooper: acooper{at}trudeauinstitute.org

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40–deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40–deficient DCs with IL-12p40 homodimer (IL-12(p40)₂) restores Mtb-induced DC migration and the ability of IL-12p40–deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs.

S. Partida-Sanchez's present address is Columbus Children's Research Institute, Columbus, OH 43205.

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