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The E enhancer controls the generation of CD4^–CD8^– ßTCR-expressing T cells that can give rise to different lineages of ß T cells

¹ Dana-Farber Cancer Institute and ² Children's Hospital, Harvard Medical School, Boston, MA 02115
³ University of Pennsylvania School of Medicine, Philadelphia, PA 19104
⁴ Department of Medicine, The University of Chicago, Chicago, IL 60637

CORRESPONDENCE Harald von Boehmer: harald_von_boehmer{at}dfci.harvard.edu

It is well established that the pre–T cell receptor for antigen (TCR) is responsible for efficient expansion and differentiation of thymocytes with productive TCRß rearrangements. However, Ptcra- as well as Tcra-targeting experiments have suggested that the early expression of Tcra in CD4^–CD8^– cells can partially rescue the development of ß CD4⁺CD8⁺ cells in Ptcra-deficient mice. In this study, we show that the TCR E but not E enhancer function is required for the cell surface expression of ßTCR on immature CD4^–CD8^– T cell precursors, which play a crucial role in promoting ß T cell development in the absence of pre-TCR. Thus, ßTCR expression by CD4^–CD8^– thymocytes not only represents a transgenic artifact but occurs under physiological conditions.

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• Leng, Q., Ge, Q., Nguyen, T., Eisen, H. N., Chen, J. (2007). Stage-dependent reactivity of thymocytes to self-peptide-MHC complexes. Proc. Natl. Acad. Sci. USA 104: 5038-5043 [Abstract] [Full Text]  

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