Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhu, Y. Articles by Marrack, P. Search for Related Content PubMed PubMed Citation Articles by Zhu, Y. Articles by Marrack, P. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Social Bookmarking                      What's this?

¹ Department of Biochemistry and Molecular Genetics, ² Department of Pharmacology, and ³ Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80220
⁴ Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206
⁵ Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229

CORRESPONDENCE Philippa Marrack: marrackp{at}njc.org

The introduction of antigen into animals causes antigen-specific T cells to divide and then die. Activated T cell death requires either of the death effector molecules, Bak or Bax. When T cells die, Bak and Bax change their conformations, a phenomenon that is thought to be required for Bak or Bax to drive cell death. Here we show that Bak changes conformation before activated T cells die, as detected by an antibody specific for a peptide near the NH₂ terminus of Bak, but Bax does not change its shape markedly until after the cells are dead, as detected by an antibody specific for a peptide near the NH₂ terminus of Bax. This latter finding is also true in activated T cells that lack Bak and are therefore dependent on Bax to die. This result suggests that Bax does not have to adopt its final, completely unfolded form until after the cells are dead.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Liu, X., Zhu, Y., Dai, S., White, J., Peyerl, F., Kappler, J. W., Marrack, P. (2006). Bcl-xl does not have to bind Bax to protect T cells from death. J. Exp. Med. 203: 2953-2961 [Abstract] [Full Text]  
• Ying, S., Fischer, S. F., Pettengill, M., Conte, D., Paschen, S. A., Ojcius, D. M., Hacker, G. (2006). Characterization of Host Cell Death Induced by Chlamydia trachomatis. Infect. Immun. 74: 6057-6066 [Abstract] [Full Text]  
• Zhu, Y., Liu, X., Hildeman, D., Peyerl, F. W., White, J., Kushnir, E., Kappler, J., Marrack, P. (2006). Bax does not have to adopt its final form to drive T cell death. J. Cell Biol. 173: i8-i8 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS