The Journal of Experimental Medicine
Torrey Pines Biolabs
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Published online 27 March 2006 doi:10.1084/jem.20051954
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 4, 1045-1054
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ARTICLE

 CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

Drew M. Catron, Lori K. Rusch, Jason Hataye, Andrea A. Itano, and Marc K. Jenkins

Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455

CORRESPONDENCE Drew M. Catron: catro001{at}umn.edu

We explored the relationship between the time of naive CD4+ T cell exposure to antigen in the primary immune response and the quality of the memory cells produced. Naive CD4+ T cells that migrated into the skin-draining lymph nodes after subcutaneous antigen injection accounted for about half of the antigen-specific population present at the peak of clonal expansion. These late-arriving T cells divided less and more retained the central–memory marker CD62L than the T cells that resided in the draining lymph nodes at the time of antigen injection. The fewer cell divisions were related to competition with resident T cells that expanded earlier in the response and a reduction in the number of dendritic cells displaying peptide–major histocompatibility complex (MHC) II complexes at later times after antigen injection. The progeny of late-arriving T cells possessed the phenotype of central–memory cells, and proliferated more extensively during the secondary response than the progeny of the resident T cells. The results suggest that late arrival into lymph nodes and exposure to antigen-presenting cells displaying lower numbers of peptide–MHC II complexes in the presence of competing T cells ensures that some antigen-specific CD4+ T cells divide less in the primary response and become central–memory cells.

Abbreviation used: HA, hemagglutinin.

A.A. Itano's present address is Amgen, Thousand Oaks, CA 91320.


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