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¹ Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, and ² Department of Pathology, New York University School of Medicine, New York, NY 10016

CORRESPONDENCE Juan J. Lafaille: lafaille{at}saturn.med.nyu.edu OR Michael L. Dustin: dustin{at}saturn.med.nyu.edu

Regulatory T (T reg) cells exert powerful down-modulatory effects on immune responses, but it is not known how they act in vivo. Using intravital two-photon laser scanning microscopy we determined that, in the absence of T reg cells, the locomotion of autoantigen-specific T cells inside lymph nodes is decreased, and the contacts between T cells and antigen-loaded dendritic cells (DCs) are of longer duration. Thus, T reg cells can exert an early effect on immune responses by attenuating the establishment of stable contacts during priming of naive T cells by DCs.

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