The Journal of Experimental Medicine
StemCell Technologies
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Published online 13 March 2006 doi:10.1084/jem.20060217
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 3, 493-495
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COMMENTARY

 Are hemostasis and thrombosis two sides of the same coin?

Robert W. Colman

R.W.C. is at Sol Sherry Thrombosis Research Center and Hematology Division, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.

CORRESPONDENCE R.W.C.: colmanr{at}temple.edu


Abstract
Factor XII (FXII), a clotting enzyme that can initiate coagulation in vitro, has long been considered dispensable for normal blood clotting in vivo because hereditary deficiencies in FXII are not associated with spontaneous or excessive bleeding. However, new studies show that mice lacking FXII are protected against arterial thrombosis (obstructive clot formation) and stroke. Thus, FXII could be a unique drug target that could be blocked to prevent thrombosis without the side effect of increased bleeding.


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