Published online 13 February 2006 doi:10.1084/jem.20052036
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 2, 305-310
T-independent type II immune responses generate memory B cells
Tetyana V. Obukhanych1 and
Michel C. Nussenzweig1,2
1 Laboratory of Molecular Immunology and 2 Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021
CORRESPONDENCE Michel C. Nussenzweig: nussen{at}rockefeller.edu
Unlike T-dependent immune responses against protein antigens, T-independent responses against polysaccharides confer long-lasting humoral immunity in the absence of recall responses and are not known to generate memory B cells. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. Furthermore, memory B cell responses against polysaccharides are regulated by antigen-specific immunoglobulin G antibodies. As the generation and regulation of immunologic memory is central to vaccination, our findings help explain the mode of action of the few existing polysaccharide vaccines and provide a rationale for a wider application of polysaccharide-based strategies in vaccination.
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