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Published online 25 September 2006 doi:10.1084/jem.20060998
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 203, Number 10, 2233-2237
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COMMENTARY

 Synergy between the pre–T cell receptor and Notch: cementing the {alpha}ß lineage choice

Cynthia J. Guidos

CORRESPONDENCE C.J.G.: Cynthia.guidos{at}sickkids.ca


ABSTRACT
Notch1 signaling suppresses B cell development and promotes T lineage commitment in thymus-seeding hematopoietic progenitors. Notch1 is also activated in early T cell progenitors, but the functions of these later Notch signals have not been clearly defined. Recent studies reveal that Notch signaling is not essential for pre–T cell receptor (TCR) expression or {gamma}{delta} lineage choice. Rather, pre-TCR signaling enhances progenitor competitiveness for limiting Notch ligands, leading to preferential expansion of TCRß-bearing progenitors.

C.J.G. is at Program in Developmental Biology, Hospital for Sick Children Research Institute, and Department of Immunology, Faculty of Medicine, University of Toronto Toronto, ON Canada M5G 1L7


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