The Journal of Experimental Medicine
StemCell Technologies
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Published 1 August 2005. doi:10.1084/jem.20050176
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 3, 371-377
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BRIEF DEFINITIVE REPORT

 CD28 costimulatory signal induces protein arginine methylation in T cells

Fabien Blanchet1, Ana Cardona2, Fabrice A. Letimier1, Michael S. Hershfield3, and Oreste Acuto1

1 Molecular Immunology Unit, Institut Pasteur, Paris 75015, Cedex 15, France
2 Histotechnology and Pathology Unit, Institut Pasteur, Paris 75015, Cedex 15, France
3 Department of Medicine and Biochemistry, Duke University Medical Center, Durham, NC 27710

CORRESPONDENCE Oreste Acuto: oacuto{at}pasteur.fr

Protein phosphorylation initiates signal transduction that triggers lymphocyte activation. However, other posttranslational modifications may contribute to this process. Here, we show that CD28 engagement induced protein arginine methyltransferase activity and methylation on arginine of several proteins, including Vav1. Methylation of Vav1 and IL-2 production were reduced by inhibiting S-adenosyl-L-homocysteine hydrolase, an enzyme that regulates cellular transmethylation. Methylated Vav1 was induced in human and mouse T cells and selectively localized in the nucleus, which suggested that this form marks a nuclear function of Vav1. Our findings uncover a signaling pathway that is controlled by CD28 that is likely to be important for T cell activation.


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