Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Groothuis, T. A.M. Articles by Neefjes, J. Search for Related Content PubMed PubMed Citation Articles by Groothuis, T. A.M. Articles by Neefjes, J. Social Bookmarking                      What's this?

T.A.M.G. and J.N. are at Div. of Tumor Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

CORRESPONDENCE J.N.: J.NEEFJES{at}NKI.NL

Abstract
Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system, in which the machinery required for peptide loading of MHC class I molecules is introduced directly into the phagosome. Here, we discuss the evidence for and against the ER-phagosome concept as well as other possible mechanisms of cross-presentation.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Eng, E. W., Bettio, A., Ibrahim, J., Harrison, R. E. (2007). MTOC Reorientation Occurs during Fc{gamma}R-mediated Phagocytosis in Macrophages. Mol. Biol. Cell 18: 2389-2399 [Abstract] [Full Text]  
• Burgdorf, S., Kautz, A., Bohnert, V., Knolle, P. A., Kurts, C. (2007). Distinct Pathways of Antigen Uptake and Intracellular Routing in CD4 and CD8 T Cell Activation. Science 316: 612-616 [Abstract] [Full Text]  
• Leclerc, D., Beauseigle, D., Denis, J., Morin, H., Pare, C., Lamarre, A., Lapointe, R. (2007). Proteasome-Independent Major Histocompatibility Complex Class I Cross-Presentation Mediated by Papaya Mosaic Virus-Like Particles Leads to Expansion of Specific Human T Cells. J. Virol. 81: 1319-1326 [Abstract] [Full Text]  
• Krawczyk, M., Leimgruber, E., Seguin-Estevez, Q., Dunand-Sauthier, I., Barras, E., Reith, W. (2007). Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genes. Nucleic Acids Res 35: 595-605 [Abstract] [Full Text]  
• Bertholet, S., Goldszmid, R., Morrot, A., Debrabant, A., Afrin, F., Collazo-Custodio, C., Houde, M., Desjardins, M., Sher, A., Sacks, D. (2006). Leishmania Antigens Are Presented to CD8+ T Cells by a Transporter Associated with Antigen Processing-Independent Pathway In Vitro and In Vivo. J. Immunol. 177: 3525-3533 [Abstract] [Full Text]  
• Hatsuzawa, K., Tamura, T., Hashimoto, H., Hashimoto, H., Yokoya, S., Miura, M., Nagaya, H., Wada, I. (2006). Involvement of Syntaxin 18, an Endoplasmic Reticulum (ER)-localized SNARE Protein, in ER-mediated Phagocytosis. Mol. Biol. Cell 17: 3964-3977 [Abstract] [Full Text]  
• Groothuis, T. A.M., Neefjes, J. (2005). The many roads to cross-presentation. J. Cell Biol. 171: i11-i11 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS