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^a G.O.G. is at the Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195.
^b A.G.F. is at the Department of Immunology and Department of Biostructure, University of Washington School of Medicine, Seattle, WA 98195.

CORRESPONDENCE A.G.F.: farr{at}u.washington.edu

Abstract
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

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