Differential contributions of central and effector memory T cells to recall responses

doi:10.1084/jem.20050137

Published online 27 June 2005 doi:10.1084/jem.20050137
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 202, Number 1, 123-133

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ARTICLE

Differential contributions of central and effector memory T cells to recall responses

Alan D. Roberts, Kenneth H. Ely, and David L. Woodland

Trudeau Institute, Saranac Lake, NY 12983

CORRESPONDENCE David L. Woodland: dwoodland{at}trudeauinstitute.org

Although the absolute number of memory CD8⁺ T cells establishedin the spleen following antigen encounter remains stable formany years, the relative capacity of these cells to mediaterecall responses is not known. Here we used a dual adoptivetransfer approach to demonstrate a progressive increase in thequality of memory T cell pools in terms of their ability toproliferate and accumulate at effector sites in response tosecondary pathogen challenge. This temporal increase in efficacyoccurred in CD62L^lo (effector memory) and CD62L^hi (central memory)subpopulations, but was most prominent in the CD62L^hi subpopulation.These data indicate that the contribution of effector memoryand central memory T cells to the recall response changes substantiallyover time.

Abbreviations used: MLN, mediastinal lymph node; NP, nucleoprotein;PCL, pleural cavity lavage.

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