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C.A.D. is at Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262.

CORRESPONDENCE C.A.D.: cdinare333{at}aol.com

Abstract
A growing number of systemic inflammatory diseases characterized in part by recurrent fevers, leukocytosis, anemia, and elevated acute phase proteins are linked to interleukin (IL)-1 activity since rapid and sustained resolution is observed upon specific blockade of IL-1 receptors. Rapid resolution of systemic and local inflammation is now also reported in systemic onset juvenile idiopathic arthritis (SoJIA). Loss of control of the secretion of IL-1ß might be a common mechanism explaining the aberrant activity of IL-1 in these diseases.

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