The Journal of Experimental Medicine
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Published 21 March 2005. doi:10.1084/jem.20050339
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 6, 833-836
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COMMENTARY

 Signaling for NKT cell development : the SAP–FynT connection



Christine Borowski and Albert Bendelac

C.B. and A.B. are at the University of Chicago, Chicago, IL 60637.

CORRESPONDENCE A.B.: abendela{at}bsd.uchicago.edu


Abstract
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seemingly disparate observations characterizing NKT cell development. In fact, SAP-dependent signaling may underlie the development of multiple unconventional T cell lineages whose thymic selection relies on homotypic interactions between hematopoietic cells.


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