The Journal of Experimental Medicine
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Published 7 March 2005. doi:10.1084/jem.20050222
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 5, 671-674
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COMMENTARY

 Controlling inflammation : a fat chance?



Roderick J. Flower and Mauro Perretti

R.J.F. and M.P. are at The William Harvey Research Institute, London EC1M 6BQ, UK.

CORRESPONDENCE R.J.F.: r.j.flower{at}qmul.ac.uk OR M.P.: m.perretti{at}qmul.ac.uk


Abstract
The inflammatory response protects the body against infection and injury but can itself become deregulated with deleterious consequences to the host. It is now clear that several endogenous biochemical pathways activated during defense reactions can counterregulate inflammation. New experimental evidence adds resolvin E1 to this group of endogenous inhibitors and provides further rationale for the beneficial effects of dietary supplementation with fish oils. It also highlights an unexpected twist in the pharmacology of aspirin.


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J. Exp. Med. 2005 201: 713-722. [Abstract] [Full Text] [PDF]



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