The Journal of Experimental Medicine
StemCell Technologies
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Published 22 February 2005. doi:10.1084/jem.20041310
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 4, 509-515
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BRIEF DEFINITIVE REPORT

 Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin

William Vermi1, Elena Riboldi2, Valerie Wittamer3, Francesca Gentili1, Walter Luini4, Simona Marrelli1, Annunciata Vecchi4, Jean-Denis Franssen5, David Communi3, Luisa Massardi2, Marina Sironi4, Alberto Mantovani4,6, Marc Parmentier3, Fabio Facchetti1, and Silvano Sozzani2,4

1 Department of Pathology, University of Brescia, 25123 Brescia, Italy
2 Section of General Pathology and Immunology, University of Brescia, 25123 Brescia, Italy
3 Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Campus Erasme, B-1070 Brussels, Belgium
4 Istituto Ricerche Farmacologiche "Mario Negri, " 20157 Milan, Italy
5 Euroscreen S.A., B-6041 Gosselies, Belgium
6 Centro IDET, Institute of General Pathology, University of Milan, 20133 Milan, Italy

CORRESPONDENCE Silvano Sozzani: sozzani{at}med.unibs.it

Chemerin is a chemotactic agent that was recently identified as the ligand of ChemR23, a serpentine receptor expressed by activated macrophages and monocyte-derived dendritic cells (DCs). This paper shows that blood plasmacytoid and myeloid DCs express functional ChemR23. Recombinant chemerin induced the transmigration of plasmacytoid and myeloid DCs across an endothelial cell monolayer. In secondary lymphoid organs (lymph nodes and tonsils), ChemR23 is expressed by CD123+ plasmacytoid DCs and by CD1a+ DC-SIGN+ DCs in the interfollicular T cell area. ChemR23+ DCs were also observed in dermis from normal skin, whereas Langerhans cells were negative. Chemerin expression was selectively detected on the luminal side of high endothelial venules in secondary lymphoid organs and in dermal endothelial vessels of lupus erythematosus skin lesions. Chemerin+ endothelial cells were surrounded by ChemR23+ plasmacytoid DCs. Thus, ChemR23 is expressed and functional in plasmacytoid DCs, a property shared only by CXCR4 among chemotactic receptors. This finding, together with the selective expression of the cognate ligand on the luminal side of high endothelial venules and inflamed endothelium, suggests a key role of the ChemR23/chemerin axis in directing plasmacytoid DC trafficking.


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