Published 22 February 2005. doi:10.1084/jem.20050218
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 4, 497-499
Selecting B cells and plasma cells to memory
Thomas Dörner and
Andreas Radbruch
T.D. and A.R. are at University Hospital Berlin and Deutsches Rheumaforschungszentrum Berlin, 10098 Berlin, Germany.
CORRESPONDENCE T.D.: thomas.doerner{at}charite.de
Abstract
Humoral immunity appears to be based on immunological memory provided by memory plasma cells, which secrete protective antibodies, and memory B cells, which react to antigen challenge by differentiating into plasma cells. How these differentiation pathways relate to each other, how cells are selected into these memory populations, and how these populations are maintained remains enigmatic.
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