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Susan E. Levin and Arthur Weiss

S.E.L. and A.W. are at The Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143

CORRESPONDENCE A.W.: aweiss{at}medicine.ucsf.edu

Abstract
The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR conformational change is reviewed and potential mechanisms for its initiation are explored.

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