The Journal of Experimental Medicine
VISIT JCB ONLINE!
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 6 June 2005. doi:10.1084/jem.20042284
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 11, 1725-1731
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tester, I.
Right arrow Articles by Rosen, H. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tester, I.
Right arrow Articles by Rosen, H. R.
Right arrowPubmed/NCBI databases
*Nucleotide*Protein
Medline Plus Health Information
*Hepatitis C
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

BRIEF DEFINITIVE REPORT

 Immune evasion versus recovery after acute hepatitis C virus infection from a shared source

Ian Tester1,2, Susan Smyk-Pearson1,2, Ping Wang3, Anne Wertheimer2, Ermei Yao3, David M. Lewinsohn1,2, John E. Tavis3,4, and Hugo R. Rosen1,2

1 Department of Medicine, Portland Veterans Administration Medical Center
2 Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland OR 97239
3 Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine
4 Saint Louis University Liver Center, St. Louis, MO 63103

CORRESPONDENCE Hugo R. Rosen: Hugo.Rosen{at}UCHSC.edu

Acute infection with hepatitis C virus (HCV) rarely is identified, and hence, the determinants of spontaneous resolution versus chronicity remain incompletely understood. In particular, because of the retrospective nature and unknown source of infection in most human studies, direct evidence for emergence of escape mutations in immunodominant major histocompatibility complex class I–restricted epitopes leading to immune evasion is extremely limited. In two patients infected accidentally with an identical HCV strain but who developed divergent outcomes, the total lack of HCV-specific CD4+ T cells in conjunction with vigorous CD8+ T cells that targeted a single epitope in one patient was associated with mutational escape and viral persistence. Statistical evidence for positive Darwinian selective pressure against an immunodominant epitope is presented. Wild-type cytotoxic T lymphocytes persisted even after the cognate antigen was no longer present.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS