Published 3 January 2005. doi:10.1084/jem.20042111
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 1, 7-9
Do developing B cells need antigen?
Jean-Claude Weill and
Claude-Agnès Reynaud
J.-C.W. and C.-A.R. are at INSERM U373, Faculté de Médecine René Descartes, 75730 Paris Cedex 15, France.
CORRESPONDENCE J.-C.W.: weill{at}necker.fr OR C.-A.R.: reynaud{at}necker.fr
Abstract
Just as potentially useful T cells are positively selected by MHC–peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations with the capacity to recognize polysaccharide or protein structures on pathogens. Recent studies indicate that the repertoire of B cells entering the periphery is not shaped by specific stimuli, but that mature B cell subsets may be under different selective pressures.
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