The Journal of Experimental Medicine
Cytokines Montreal 2008
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Published 3 January 2005. doi:10.1084/jem.20032000
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 201, Number 1, 35-39
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Brief Definitive Report

 TACI and BAFF-R mediate isotype switching in B cells

Emanuela Castigli1, Stephen A. Wilson1, Sumi Scott1, Fatma Dedeoglu1, Shengli Xu2, Kong-Peng Lam2, Richard J. Bram3, Haifa Jabara1, and Raif S. Geha1

1 Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115
2 Institute of Molecular and Cell Biology, Singapore 117609
3 Department of Immunology, Mayo Medical and Graduate Schools, Rochester, MN 55905

CORRESPONDENCE Raif S. Geha: raif.geha{at}tch.harvard.edu

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.


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