Published 20 September 2004. doi:10.1084/jem.20041464
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 6, 697-700
Getting to the Guts of HIV Pathogenesis
Ronald S. Veazey and
Andrew A. Lackner
Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433
Address correspondence to Ronald A. Veazey, Tulane National Primate Research Center, 18703 Three Rivers Rd., Covington, LA 70433. Phone: (985) 871-6228; Fax: (985) 871-6510; email: rveazey{at}tulane.edu
Abstract
Two groups have shown that, as in macaques infected with simian immunodeficiency virus (SIV), intestinal CD4+ T cells are selectively and rapidly depleted in the intestine of HIV-infected patients. Depletion of intestinal CD4+ T cells occurred at all stages of infection regardless of highly active antiretroviral therapy (HAART). Here we discuss the important implications of these papers for our understanding of HIV pathogenesis, treatment, and vaccine design.
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