Published 17 May 2004. doi:10.1084/jem.20040730
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 10, 1301-1304
Epstein-Barr Virus Nuclear Antigen 1
:
from Immunologically Invisible to a Promising T Cell Target
Christian Münz
Laboratory of Viral Immunobiology, and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021
Address correspondence to Christian Münz, Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327-7611; Fax: (212) 327-7887; email: munzc{at}rockefeller.edu
Abstract
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)the one EBV antigen that is expressed in all EBV-associated malignancieshas long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers.

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