The Journal of Experimental Medicine
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Published 17 May 2004. doi:10.1084/jem.20040730
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 10, 1301-1304
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Commentary

Epstein-Barr Virus Nuclear Antigen 1 : from Immunologically Invisible to a Promising T Cell Target



Christian Münz

Laboratory of Viral Immunobiology, and Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021

Address correspondence to Christian Münz, Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327-7611; Fax: (212) 327-7887; email: munzc{at}rockefeller.edu


Abstract
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)—the one EBV antigen that is expressed in all EBV-associated malignancies—has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers.



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