Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Honda, K. Articles by Fukuda, T. Search for Related Content PubMed PubMed Citation Articles by Honda, K. Articles by Fukuda, T. Social Bookmarking                      What's this?

¹ Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Tochigi 321-0293, Japan
² Department of Developmental Genetics, Graduate School of Medicine Chiba University, Chiba 260-8670, Japan
³ Department of Immunology and Infectious Diseases, Shinshu University Graduate School of Medicine, Matsumoto 390-8621, Japan

Address correspondence to Dr. Takeshi Fukuda, Dept. of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine, Mibu-machi Shimotsuga-gun, Tochigi 321-0293, Japan. Phone: 81-282-87-2151; Fax: 81-282-86-5080; email: t-fukuda{at}dokkyomed.ac.jp

PGD₂, a lipid mediator released from mast cells, is known to participate in allergic reactions. However, the mechanism by which PGD₂ contributes to such reactions remains unclear. We established a novel experimental model of asthma that permitted direct assessment of the role of PGD₂ in airway inflammation. Antigen-sensitized mice were exposed to aerosolized prostaglandin D₂ (PGD₂) 1 d before challenge with low-dose aerosolized antigen. Not only the numbers of eosinophils, lymphocytes, and macrophages but also the levels of IL-4 and IL-5 in bronchoalveolar lavage fluid were higher in PGD₂-pretreated mice than in control mice. The expression of macrophage-derived chemokine (MDC), a chemoattractant for Th2 cells, was greater in PGD₂-pretreated mice than in control. Injection of anti-MDC antibody into PGD₂-pretreated mice markedly inhibited inflammatory cell infiltration as well as Th2 cyto-kine production after antigen challenge. These results indicate that PGD₂ accelerates Th2 type inflammation by induction of MDC. Our results suggest that this mechanism may play a key role in the development of human asthma and that MDC might be a target molecule for therapeutic intervention.

Key Words: bronchial asthma • chemokines • epithelial cells • prostanoids • Th2 cells

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Nomiya, R., Okano, M., Fujiwara, T., Maeda, M., Kimura, Y., Kino, K., Yokoyama, M., Hirai, H., Nagata, K., Hara, T., Nishizaki, K., Nakamura, M. (2008). CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice. J. Immunol. 180: 5680-5688 [Abstract] [Full Text]  
• Shiraishi, Y., Asano, K., Niimi, K., Fukunaga, K., Wakaki, M., Kagyo, J., Takihara, T., Ueda, S., Nakajima, T., Oguma, T., Suzuki, Y., Shiomi, T., Sayama, K., Kagawa, S., Ikeda, E., Hirai, H., Nagata, K., Nakamura, M., Miyasho, T., Ishizaka, A. (2008). Cyclooxygenase-2/Prostaglandin D2/CRTH2 Pathway Mediates Double-Stranded RNA-Induced Enhancement of Allergic Airway Inflammation. J. Immunol. 180: 541-549 [Abstract] [Full Text]  
• Taniguchi, H., Mohri, I., Okabe-Arahori, H., Aritake, K., Wada, K., Kanekiyo, T., Narumiya, S., Nakayama, M., Ozono, K., Urade, Y., Taniike, M. (2007). Prostaglandin D2 Protects Neonatal Mouse Brain from Hypoxic Ischemic Injury. J. Neurosci. 27: 4303-4312 [Abstract] [Full Text]  
• Hammad, H., Kool, M., Soullie, T., Narumiya, S., Trottein, F., Hoogsteden, H. C., Lambrecht, B. N. (2007). Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells. J. Exp. Med. 204: 357-367 [Abstract] [Full Text]  
• Payne, S. G., Oskeritzian, C. A., Griffiths, R., Subramanian, P., Barbour, S. E., Chalfant, C. E., Milstien, S., Spiegel, S. (2007). The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 109: 1077-1085 [Abstract] [Full Text]  
• Park, G. Y., Christman, J. W. (2006). Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L797-L805 [Abstract] [Full Text]  
• Shimizu, K., Mitchell, R. N., Libby, P. (2006). Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms. Arterioscler. Thromb. Vasc. Bio. 26: 987-994 [Abstract] [Full Text]  
• Mesquita-Santos, F. P., Vieira-de-Abreu, A., Calheiros, A. S., Figueiredo, I. H., Castro-Faria-Neto, H. C., Weller, P. F., Bozza, P. T., Diaz, B. L., Bandeira-Melo, C. (2006). Cutting Edge: Prostaglandin D2 Enhances Leukotriene C4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic In Vivo Role of Endogenous Eotaxin. J. Immunol. 176: 1326-1330 [Abstract] [Full Text]  
• Georas, S. N., Guo, J., De Fanis, U., Casolaro, V. (2005). T-helper cell type-2 regulation in allergic disease. Eur Respir J 26: 1119-1137 [Abstract] [Full Text]  
• Hata, A. N., Lybrand, T. P., Breyer, R. M. (2005). Identification of Determinants of Ligand Binding Affinity and Selectivity in the Prostaglandin D2 Receptor CRTH2. J. Biol. Chem. 280: 32442-32451 [Abstract] [Full Text]  
• Noguchi, J., Kuroda, E., Yamashita, U. (2005). Strain difference of murine bone marrow-derived mast cell functions. J. Leukoc. Biol. 78: 605-611 [Abstract] [Full Text]  
• Almishri, W., Cossette, C., Rokach, J., Martin, J. G., Hamid, Q., Powell, W. S. (2005). Effects of Prostaglandin D2, 15-Deoxy-{Delta}12,14-prostaglandin J2, and Selective DP1 and DP2 Receptor Agonists on Pulmonary Infiltration of Eosinophils in Brown Norway Rats. J. Pharmacol. Exp. Ther. 313: 64-69 [Abstract] [Full Text]  
• Spik, I., Brenuchon, C., Angeli, V., Staumont, D., Fleury, S., Capron, M., Trottein, F., Dombrowicz, D. (2005). Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse. J. Immunol. 174: 3703-3708 [Abstract] [Full Text]  
• Shiraishi, Y., Asano, K., Nakajima, T., Oguma, T., Suzuki, Y., Shiomi, T., Sayama, K., Niimi, K., Wakaki, M., Kagyo, J., Ikeda, E., Hirai, H., Yamaguchi, K., Ishizaka, A. (2005). Prostaglandin D2-Induced Eosinophilic Airway Inflammation Is Mediated by CRTH2 Receptor. J. Pharmacol. Exp. Ther. 312: 954-960 [Abstract] [Full Text]  
• Mandal, A. K., Zhang, Z., Ray, R., Choi, M. S., Chowdhury, B., Pattabiraman, N., Mukherjee, A. B. (2004). Uteroglobin Represses Allergen-induced Inflammatory Response by Blocking PGD2 Receptor-mediated Functions. J. Exp. Med. 199: 1317-1330 [Abstract] [Full Text]  
• Inoue, T., Okano, Y., Kado, Y., Aritake, K., Irikura, D., Uodome, N., Okazaki, N., Kinugasa, S., Shishitani, H., Matsumura, H., Kai, Y., Urade, Y. (2004). First Determination of the Inhibitor Complex Structure of Human Hematopoietic Prostaglandin D Synthase. J Biochem 135: 279-283 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS