Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Woerly, G. Articles by Dombrowicz, D. Search for Related Content PubMed PubMed Citation Articles by Woerly, G. Articles by Dombrowicz, D. Social Bookmarking                      What's this?

Peroxisome Proliferator–activated Receptors and Down-regulate Allergic Inflammation and Eosinophil Activation

¹ Institut National de la Santé et de la Recherche Médicale (INSERM), U547-IFR17, Institut Pasteur de Lille, 59019 Lille, France
² INSERM U545, Institut Pasteur de Lille and Faculté de Pharmacie, Université de Lille II, 59019 Lille, France
³ Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS)/INSERM/Université Louis Pasteur, 67401 Ilkirch, France

Address correspondence to David Dombrowicz, Institut National de la Santé et de la Recherche Médicale U547, Institut Pasteur de Lille 1, rue Prof. Calmette BP245, 59019 Lille Cedex, France. Phone: 33-03-20-87-79-67; Fax: 33-03-20-87-78-88; email: david.dombrowicz{at}pasteur-lille.fr

Allergic asthma is characterized by airway hyperresponsiveness, eosinophilia, and mucus accumulation and is associated with increased IgE concentrations. We demonstrate here that peroxisome proliferator–activated receptors (PPARs), PPAR- and PPAR-, which have been shown recently to be involved in the regulation of various cell types within the immune system, decrease antigen-induced airway hyperresponsiveness, lung inflammation, eosinophilia, cytokine production, and GATA-3 expression as well as serum levels of antigen-specific IgE in a murine model of human asthma. In addition, we demonstrate that PPAR- and - are expressed in eosinophils and their activation inhibits in vitro chemotaxis and antibody-dependent cellular cytotoxicity. Thus, PPAR- and - (co)agonists might be of therapeutic interest for the regulation of allergic or inflammatory reactions by targeting both regulatory and effector cells involved in the immune response.

Key Words: nuclear receptors • asthma • eosinophils • IgE • ADCC

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Belvisi, M. G., Hele, D. J. (2008). Peroxisome Proliferator-Activated Receptors as Novel Targets in Lung Disease. Chest 134: 152-157 [Abstract] [Full Text]  
• Jaudszus, A., Krokowski, M., Mockel, P., Darcan, Y., Avagyan, A., Matricardi, P., Jahreis, G., Hamelmann, E. (2008). Cis-9,trans-11-Conjugated Linoleic Acid Inhibits Allergic Sensitization and Airway Inflammation via a PPAR{gamma}-Related Mechanism in Mice. J. Nutr. 138: 1336-1342 [Abstract] [Full Text]  
• Behshad, R., Cooper, K. D., Korman, N. J. (2008). A Retrospective Case Series Review of the Peroxisome Proliferator-Activated Receptor Ligand Rosiglitazone in the Treatment of Atopic Dermatitis. Arch Dermatol 144: 84-88 [Abstract] [Full Text]  
• Haworth, O., Levy, B. D. (2007). Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J 30: 980-992 [Abstract] [Full Text]  
• Nakagome, K., Dohi, M., Okunishi, K., Tanaka, R., Kouro, T., Kano, M. R., Miyazono, K., Miyazaki, J.-i., Takatsu, K., Yamamoto, K. (2007). IL-5-Induced Hypereosinophilia Suppresses the Antigen-Induced Immune Response via a TGF-beta-Dependent Mechanism. J. Immunol. 179: 284-294 [Abstract] [Full Text]  
• Wohlfert, E. A., Nichols, F. C., Nevius, E., Clark, R. B. (2007). Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) and Immunoregulation: Enhancement of Regulatory T Cells through PPAR{gamma}-Dependent and -Independent Mechanisms. J. Immunol. 178: 4129-4135 [Abstract] [Full Text]  
• Tilley, S. L., Jaradat, M., Stapleton, C., Dixon, D., Hua, X., Erikson, C. J., McCaskill, J. G., Chason, K. D., Liao, G., Jania, L., Koller, B. H., Jetten, A. M. (2007). Retinoid-Related Orphan Receptor {gamma} Controls Immunoglobulin Production and Th1/Th2 Cytokine Balance in the Adaptive Immune Response to Allergen. J. Immunol. 178: 3208-3218 [Abstract] [Full Text]  
• Sandig, H., Pease, J. E., Sabroe, I. (2007). Contrary prostaglandins: the opposing roles of PGD2 and its metabolites in leukocyte function. J. Leukoc. Biol. 81: 372-382 [Abstract] [Full Text]  
• Maeda, Y., Dave, V., Whitsett, J. A. (2007). Transcriptional Control of Lung Morphogenesis. Physiol. Rev. 87: 219-244 [Abstract] [Full Text]  
• Kang, H. J., Cinn, Y.-G., Hwang, S. J., Won Chae, S., Woo, J.-S., Lee, S. H., Lee, H.-M. (2006). Up-regulation of Peroxisome Proliferator-Activated Receptor {gamma} in Perennial Allergic Rhinitis.. Arch Otolaryngol Head Neck Surg 132: 1196-1200 [Abstract] [Full Text]  
• Lee, K. S., Park, S. J., Kim, S. R., Min, K. H., Jin, S. M., Lee, H. K., Lee, Y. C. (2006). Modulation of Airway Remodeling and Airway Inflammation by Peroxisome Proliferator-Activated Receptor {gamma} in a Murine Model of Toluene Diisocyanate-Induced Asthma. J. Immunol. 177: 5248-5257 [Abstract] [Full Text]  
• Simon, D. M., Arikan, M. C., Srisuma, S., Bhattacharya, S., Tsai, L. W., Ingenito, E. P., Gonzalez, F., Shapiro, S. D., Mariani, T. J. (2006). Epithelial cell PPAR{gamma} contributes to normal lung maturation. FASEB J. 20: 1507-1509 [Abstract] [Full Text]  
• Marian, E., Baraldo, S., Visentin, A., Papi, A., Saetta, M., Fabbri, L. M., Maestrelli, P. (2006). Up-Regulated Membrane and Nuclear Leukotriene B4 Receptors in COPD. Chest 129: 1523-1530 [Abstract] [Full Text]  
• August, A., Mueller, C., Weaver, V., Polanco, T. A., Walsh, E. R., Cantorna, M. T. (2006). Nutrients, Nuclear Receptors, Inflammation, Immunity Lipids, PPAR, and Allergic Asthma. J. Nutr. 136: 695-699 [Abstract] [Full Text]  
• Boxall, C., Holgate, S. T., Davies, D. E. (2006). The contribution of transforming growth factor-{beta} and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 27: 208-229 [Abstract] [Full Text]  
• Kim, S. R., Lee, K. S., Park, H. S., Park, S. J., Min, K. H., Jin, S. M., Lee, Y. C. (2005). Involvement of IL-10 in Peroxisome Proliferator-Activated Receptor {gamma}-Mediated Anti-Inflammatory Response in Asthma. Mol. Pharmacol. 68: 1568-1575 [Abstract] [Full Text]  
• Kobayashi, Y., Ueki, S., Mahemuti, G., Chiba, T., Oyamada, H., Saito, N., Kanda, A., Kayaba, H., Chihara, J. (2005). Physiological Levels of 15-Deoxy-{Delta}12,14-Prostaglandin J2 Prime Eotaxin-Induced Chemotaxis on Human Eosinophils through Peroxisome Proliferator-Activated Receptor-{gamma} Ligation. J. Immunol. 175: 5744-5750 [Abstract] [Full Text]  
• Standiford, T. J., Keshamouni, V. G., Reddy, R. C. (2005). Peroxisome Proliferator-activated Receptor-{gamma} as a Regulator of Lung Inflammation and Repair. Proc Am Thorac Soc 2: 226-231 [Abstract] [Full Text]  
• Henry, P. J., D'Aprile, A., Self, G., Hong, T., Mann, T. S. (2005). Inhibitors of Prostaglandin Transport and Metabolism Augment Protease-Activated Receptor-2-Mediated Increases in Prostaglandin E2 Levels and Smooth Muscle Relaxation in Mouse Isolated Trachea. J. Pharmacol. Exp. Ther. 314: 995-1001 [Abstract] [Full Text]  
• Spik, I., Brenuchon, C., Angeli, V., Staumont, D., Fleury, S., Capron, M., Trottein, F., Dombrowicz, D. (2005). Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse. J. Immunol. 174: 3703-3708 [Abstract] [Full Text]  
• Nie, M., Corbett, L., Knox, A. J., Pang, L. (2005). Differential Regulation of Chemokine Expression by Peroxisome Proliferator-activated Receptor {gamma} Agonists: INTERACTIONS WITH GLUCOCORTICOIDS AND {beta}2-AGONISTS. J. Biol. Chem. 280: 2550-2561 [Abstract] [Full Text]  
• Zhang, X., Rodriguez-Galan, M. C., Subleski, J. J., Ortaldo, J. R., Hodge, D. L., Wang, J.-M., Shimozato, O., Reynolds, D. A., Young, H. A. (2004). Peroxisome proliferator-activated receptor-{gamma} and its ligands attenuate biologic functions of human natural killer cells. Blood 104: 3276-3284 [Abstract] [Full Text]  
• Hammad, H., de Heer, H. J., Soullie, T., Angeli, V., Trottein, F., Hoogsteden, H. C., Lambrecht, B. N. (2004). Activation of Peroxisome Proliferator-Activated Receptor-{gamma} in Dendritic Cells Inhibits the Development of Eosinophilic Airway Inflammation in a Mouse Model of Asthma. Am. J. Pathol. 164: 263-271 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS