Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Supplemental Material Index Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, W. Articles by Wahl, S. M. Search for Related Content PubMed PubMed Citation Articles by Chen, W. Articles by Wahl, S. M. Social Bookmarking                      What's this?

Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892

Address correspondence to WanJun Chen, Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 435-7168; Fax: (301) 402-1064; email: wchen{at}dir.nidcr.nih.gov; or Sharon M. Wahl. Phone: (301) 496-4178; email: smwahl{at}dir.nidcr.nih.gov

CD4⁺CD25⁺ regulatory T cells (T_reg) are instrumental in the maintenance of immunological tolerance. One critical question is whether T_reg can only be generated in the thymus or can differentiate from peripheral CD4⁺CD25^- naive T cells. In this paper, we present novel evidence that conversion of naive peripheral CD4⁺CD25^- T cells into anergic/suppressor cells that are CD25⁺, CD45RB^-/low and intracellular CTLA-4⁺ can be achieved through costimulation with T cell receptors (TCRs) and transforming growth factor ß (TGF-ß). Although transcription factor Foxp3 has been shown recently to be associated with the development of T_reg, the physiological inducers for Foxp3 gene expression remain a mystery. TGF-ß induced Foxp3 gene expression in TCR-challenged CD4⁺CD25^- naive T cells, which mediated their transition toward a regulatory T cell phenotype with potent immunosuppressive potential. These converted anergic/suppressor cells are not only unresponsive to TCR stimulation and produce neither T helper cell 1 nor T helper cell 2 cytokines but they also express TGF-ß and inhibit normal T cell proliferation in vitro. More importantly, in an ovalbumin peptide TCR transgenic adoptive transfer model, TGF-ß–converted transgenic CD4⁺CD25⁺ suppressor cells proliferated in response to immunization and inhibited antigen-specific naive CD4⁺ T cell expansion in vivo. Finally, in a murine asthma model, coadministration of these TGF-ß–induced suppressor T cells prevented house dust mite–induced allergic pathogenesis in lungs.

Key Words: anergy • IL-10 • OVA TCR transgenic • house dust mite • asthma

Abbreviations used in this paper: 7-AAD, 7-amino-actinomycin D; CFSE, carboxy-fluorescein diacetate succinimidyl ester; HDM, house dust mite; HPRT, hypoxanthineguanine phosphoribosyl transferase; PAS, periodic acid schiff; P-Smad2/3, phosphorylated Smad2/3; T_reg, CD4⁺CD25⁺ regulatory T cells.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kaplan, J., Woodworth, L, Smith, K, Coco, J, Vitsky, A, McPherson, J. (2008). Therapeutic benefit of treatment with anti-thymocyte globulin and latent TGF-{beta}1 in the MRL/lpr lupus mouse model. Lupus 17: 822-831 [Abstract]  
• Andersson, J., Tran, D. Q., Pesu, M., Davidson, T. S., Ramsey, H., O'Shea, J. J., Shevach, E. M. (2008). CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-{beta}-dependent manner. J. Exp. Med. 205: 1975-1981 [Abstract] [Full Text]  
• Chong, M. M.W., Rasmussen, J. P., Rudensky, A. Y., Littman, D. R. (2008). The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J. Exp. Med. 205: 2005-2017 [Abstract] [Full Text]  
• Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J., Pease, L. R. (2008). Reprogrammed FoxP3+ T Regulatory Cells Become IL-17+ Antigen-Specific Autoimmune Effectors In Vitro and In Vivo. J. Immunol. 181: 3137-3147 [Abstract] [Full Text]  
• Zhu, J., Paul, W. E. (2008). CD4 T cells: fates, functions, and faults. Blood 112: 1557-1569 [Abstract] [Full Text]  
• Samon, J. B., Champhekar, A., Minter, L. M., Telfer, J. C., Miele, L., Fauq, A., Das, P., Golde, T. E., Osborne, B. A. (2008). Notch1 and TGF{beta}1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 112: 1813-1821 [Abstract] [Full Text]  
• Wilde, B., Dolff, S., Cai, X., Specker, C., Becker, J., Totsch, M., Costabel, U., Durig, J., Kribben, A., Tervaert, J. W. C., Schmid, K. W., Witzke, O. (2008). CD4+CD25+ T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener's granulomatosis. Nephrol Dial Transplant 0: gfn461v1-gfn461 [Abstract] [Full Text]  
• Guo, F., Iclozan, C., Suh, W.-K., Anasetti, C., Yu, X.-Z. (2008). CD28 Controls Differentiation of Regulatory T Cells from Naive CD4 T Cells. J. Immunol. 181: 2285-2291 [Abstract] [Full Text]  
• Alford, S. K., Longmore, G. D., Stenson, W. F., Kemper, C. (2008). CD46-Induced Immunomodulatory CD4+ T Cells Express the Adhesion Molecule and Chemokine Receptor Pattern of Intestinal T Cells. J. Immunol. 181: 2544-2555 [Abstract] [Full Text]  
• Huang, B., Lei, Z., Zhang, G.-M., Li, D., Song, C., Li, B., Liu, Y., Yuan, Y., Unkeless, J., Xiong, H., Feng, Z.-H. (2008). SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood 112: 1269-1279 [Abstract] [Full Text]  
• Fragale, A., Gabriele, L., Stellacci, E., Borghi, P., Perrotti, E., Ilari, R., Lanciotti, A., Remoli, A. L., Venditti, M., Belardelli, F., Battistini, A. (2008). IFN Regulatory Factor-1 Negatively Regulates CD4+CD25+ Regulatory T Cell Differentiation by Repressing Foxp3 Expression. J. Immunol. 181: 1673-1682 [Abstract] [Full Text]  
• Zheng, Y., Manzotti, C. N., Burke, F., Dussably, L., Qureshi, O., Walker, L. S. K., Sansom, D. M. (2008). Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3. J. Immunol. 181: 1683-1691 [Abstract] [Full Text]  
• Godebu, E., Summers-Torres, D., Lin, M. M., Baaten, B. J. G., Bradley, L. M. (2008). Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells. J. Immunol. 181: 1798-1805 [Abstract] [Full Text]  
• Nagar, M., Vernitsky, H., Cohen, Y., Dominissini, D., Berkun, Y., Rechavi, G., Amariglio, N., Goldstein, I. (2008). Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells. Int Immunol 20: 1041-1055 [Abstract] [Full Text]  
• Besin, G., Gaudreau, S., Menard, M., Guindi, C., Dupuis, G., Amrani, A. (2008). Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin-Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes. Diabetes 57: 2107-2117 [Abstract] [Full Text]  
• Sehrawat, S., Suvas, S., Sarangi, P. P., Suryawanshi, A., Rouse, B. T. (2008). In Vitro-Generated Antigen-Specific CD4+ CD25+ Foxp3+ Regulatory T Cells Control the Severity of Herpes Simplex Virus-Induced Ocular Immunoinflammatory Lesions. J. Virol. 82: 6838-6851 [Abstract] [Full Text]  
• McKarns, S. C., Schwartz, R. H. (2008). Biphasic Regulation of Il2 Transcription in CD4+ T Cells: Roles for TNF-{alpha} Receptor Signaling and Chromatin Structure. J. Immunol. 181: 1272-1281 [Abstract] [Full Text]  
• Wang, L., Pino-Lagos, K., de Vries, V. C., Guleria, I., Sayegh, M. H., Noelle, R. J. (2008). Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105: 9331-9336 [Abstract] [Full Text]  
• Gil-Guerrero, L., Dotor, J., Huibregtse, I. L., Casares, N., Lopez-Vazquez, A. B., Rudilla, F., Riezu-Boj, J. I., Lopez-Sagaseta, J., Hermida, J., Van Deventer, S., Bezunartea, J., Llopiz, D., Sarobe, P., Prieto, J., Borras-Cuesta, F., Lasarte, J. J. (2008). In Vitro and In Vivo Down-Regulation of Regulatory T Cell Activity with a Peptide Inhibitor of TGF-{beta}1. J. Immunol. 181: 126-135 [Abstract] [Full Text]  
• Ichiyama, K., Yoshida, H., Wakabayashi, Y., Chinen, T., Saeki, K., Nakaya, M., Takaesu, G., Hori, S., Yoshimura, A., Kobayashi, T. (2008). Foxp3 Inhibits ROR{gamma}t-mediated IL-17A mRNA Transcription through Direct Interaction with ROR{gamma}t. J. Biol. Chem. 283: 17003-17008 [Abstract] [Full Text]  
• Suto, A., Kashiwakuma, D., Kagami, S.-i., Hirose, K., Watanabe, N., Yokote, K., Saito, Y., Nakayama, T., Grusby, M. J., Iwamoto, I., Nakajima, H. (2008). Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205: 1369-1379 [Abstract] [Full Text]  
• Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Langa, F., Varona, R., Riethmacher, D., Si-Tahar, M., Di Santo, J. P., Eberl, G. (2008). In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ ROR{gamma}t+ T cells. J. Exp. Med. 205: 1381-1393 [Abstract] [Full Text]  
• Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G., Merkenschlager, M. (2008). T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc. Natl. Acad. Sci. USA 105: 7797-7802 [Abstract] [Full Text]  
• Loddenkemper, C., Nagorsen, D., Zeitz, M. (2008). Foxp3 and microsatellite stability phenotype in colorectal cancer. Gut 57: 725-726 [Full Text]  
• Singh, A., Carson, W. F. IV, Secor, E. R. Jr, Guernsey, L. A., Flavell, R. A., Clark, R. B., Thrall, R. S., Schramm, C. M. (2008). Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease. J. Immunol. 180: 7318-7326 [Abstract] [Full Text]  
• Chen, M.-L., Yan, B.-S., Bando, Y., Kuchroo, V. K., Weiner, H. L. (2008). Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF{beta}-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis. J. Immunol. 180: 7327-7337 [Abstract] [Full Text]  
• Sehrawat, S., Rouse, B. T. (2008). Anti-Inflammatory Effects of FTY720 against Viral-Induced Immunopathology: Role of Drug-Induced Conversion of T Cells to Become Foxp3+ Regulators. J. Immunol. 180: 7636-7647 [Abstract] [Full Text]  
• Elrefaei, M., Baker, C. A. R., Jones, N. G., Bangsberg, D. R., Cao, H. (2008). Presence of Suppressor HIV-Specific CD8+ T Cells Is Associated with Increased PD-1 Expression on Effector CD8+ T Cells. J. Immunol. 180: 7757-7763 [Abstract] [Full Text]  
• Takaki, H., Ichiyama, K., Koga, K., Chinen, T., Takaesu, G., Sugiyama, Y., Kato, S., Yoshimura, A., Kobayashi, T. (2008). STAT6 Inhibits TGF-{beta}1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor. J. Biol. Chem. 283: 14955-14962 [Abstract] [Full Text]  
• Nam, J.-S., Terabe, M., Kang, M.-J., Chae, H., Voong, N., Yang, Y.-a., Laurence, A., Michalowska, A., Mamura, M., Lonning, S., Berzofsky, J. A., Wakefield, L. M. (2008). Transforming Growth Factor {beta} Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17. Cancer Res. 68: 3915-3923 [Abstract] [Full Text]  
• Ebinuma, H., Nakamoto, N., Li, Y., Price, D. A., Gostick, E., Levine, B. L., Tobias, J., Kwok, W. W., Chang, K.-M. (2008). Identification and In Vitro Expansion of Functional Antigen-Specific CD25+ FoxP3+ Regulatory T Cells in Hepatitis C Virus Infection. J. Virol. 82: 5043-5053 [Abstract] [Full Text]  
• Kline, J., Brown, I. E., Zha, Y.-Y., Blank, C., Strickler, J., Wouters, H., Zhang, L., Gajewski, T. F. (2008). Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma. Clin. Cancer Res. 14: 3156-3167 [Abstract] [Full Text]  
• Mahic, M., Yaqub, S., Bryn, T., Henjum, K., Eide, D. M., Torgersen, K. M., Aandahl, E. M., Tasken, K. (2008). Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation. J. Leukoc. Biol. 83: 1111-1117 [Abstract] [Full Text]  
• Lutsiak, M. E. C., Tagaya, Y., Adams, A. J., Schlom, J., Sabzevari, H. (2008). Tumor-Induced Impairment of TCR Signaling Results in Compromised Functionality of Tumor-Infiltrating Regulatory T Cells. J. Immunol. 180: 5871-5881 [Abstract] [Full Text]  
• Sarangi, P. P., Sehrawat, S., Suvas, S., Rouse, B. T. (2008). IL-10 and Natural Regulatory T Cells: Two Independent Anti-Inflammatory Mechanisms in Herpes Simplex Virus-Induced Ocular Immunopathology. J. Immunol. 180: 6297-6306 [Abstract] [Full Text]  
• Richer, M. J., Straka, N., Fang, D., Shanina, I., Horwitz, M. S. (2008). Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-{beta}. Diabetes 57: 1302-1311 [Abstract] [Full Text]  
• Rynda, A., Maddaloni, M., Mierzejewska, D., Ochoa-Reparaz, J., Maslanka, T., Crist, K., Riccardi, C., Barszczewska, B., Fujihashi, K., McGhee, J. R., Pascual, D. W. (2008). Low-Dose Tolerance Is Mediated by the Microfold Cell Ligand, Reovirus Protein {sigma}1. J. Immunol. 180: 5187-5200 [Abstract] [Full Text]  
• Razmara, M., Hilliard, B., Ziarani, A. K., Chen, Y. H., Tykocinski, M. L. (2008). CTLA-4{middle dot}Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells. Int Immunol 20: 471-483 [Abstract] [Full Text]  
• Haxhinasto, S., Mathis, D., Benoist, C. (2008). The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J. Exp. Med. 205: 565-574 [Abstract] [Full Text]  
• Jarnicki, A. G., Conroy, H., Brereton, C., Donnelly, G., Toomey, D., Walsh, K., Sweeney, C., Leavy, O., Fletcher, J., Lavelle, E. C., Dunne, P., Mills, K. H. G. (2008). Attenuating Regulatory T Cell Induction by TLR Agonists through Inhibition of p38 MAPK Signaling in Dendritic Cells Enhances Their Efficacy as Vaccine Adjuvants and Cancer Immunotherapeutics. J. Immunol. 180: 3797-3806 [Abstract] [Full Text]  
• Sumpter, T. L., Payne, K. K., Wilkes, D. S. (2008). Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells. J. Leukoc. Biol. 83: 708-717 [Abstract] [Full Text]  
• Passerini, L., Allan, S. E., Battaglia, M., Di Nunzio, S., Alstad, A. N., Levings, M. K., Roncarolo, M. G., Bacchetta, R. (2008). STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol 20: 421-431 [Abstract] [Full Text]  
• Luo, X., Zhang, Q., Liu, V., Xia, Z., Pothoven, K. L., Lee, C. (2008). Cutting Edge: TGF-{beta}-Induced Expression of Foxp3 in T cells Is Mediated through Inactivation of ERK. J. Immunol. 180: 2757-2761 [Abstract] [Full Text]  
• Selvaraj, R. K., Geiger, T. L. (2008). Mitigation of Experimental Allergic Encephalomyelitis by TGF-{beta} Induced Foxp3+ Regulatory T Lymphocytes through the Induction of Anergy and Infectious Tolerance. J. Immunol. 180: 2830-2838 [Abstract] [Full Text]  
• Moisini, I., Nguyen, P., Fugger, L., Geiger, T. L. (2008). Redirecting Therapeutic T Cells against Myelin-Specific T Lymphocytes Using a Humanized Myelin Basic Protein-HLA-DR2-{zeta} Chimeric Receptor. J. Immunol. 180: 3601-3611 [Abstract] [Full Text]  
• Singh, R. P., La Cava, A., Hahn, B. H. (2008). pConsensus Peptide Induces Tolerogenic CD8+ T Cells in Lupus-Prone (NZB x NZW)F1 Mice by Differentially Regulating Foxp3 and PD1 Molecules. J. Immunol. 180: 2069-2080 [Abstract] [Full Text]  
• Bryn, T., Yaqub, S., Mahic, M., Henjum, K., Aandahl, E. M., Tasken, K. (2008). LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism. Int Immunol 20: 235-245 [Abstract] [Full Text]  
• Fernandez, M. A., Puttur, F. K., Wang, Y. M., Howden, W., Alexander, S. I., Jones, C. A. (2008). T Regulatory Cells Contribute to the Attenuated Primary CD8+ and CD4+ T Cell Responses to Herpes Simplex Virus Type 2 in Neonatal Mice. J. Immunol. 180: 1556-1564 [Abstract] [Full Text]  
• Dittrich, A. M., Erbacher, A., Specht, S., Diesner, F., Krokowski, M., Avagyan, A., Stock, P., Ahrens, B., Hoffmann, W. H., Hoerauf, A., Hamelmann, E. (2008). Helminth Infection with Litomosoides sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway Inflammation, and Hyperreactivity in a Murine Asthma Model. J. Immunol. 180: 1792-1799 [Abstract] [Full Text]  
• van Wanrooij, E. J.A., de Jager, S. C.A., van Es, T., de Vos, P., Birch, H. L., Owen, D. A., Watson, R. J., Biessen, E. A.L., Chapman, G. A., van Berkel, T. J.C., Kuiper, J. (2008). CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor-Deficient Mice. Arterioscler. Thromb. Vasc. Bio. 28: 251-257 [Abstract] [Full Text]  
• Dal Secco, V., Riccioli, A., Padula, F., Ziparo, E., Filippini, A. (2008). Mouse Sertoli Cells Display Phenotypical and Functional Traits of Antigen-Presenting Cells in Response to Interferon Gamma. Biol. Reprod. 78: 234-242 [Abstract] [Full Text]  
• Kim, Y.-J., Han, M.-K., Broxmeyer, H. E. (2008). 4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells. Blood 111: 1378-1386 [Abstract] [Full Text]  
• Torcia, M. G., Santarlasci, V., Cosmi, L., Clemente, A., Maggi, L., Mangano, V. D., Verra, F., Bancone, G., Nebie, I., Sirima, B. S., Liotta, F., Frosali, F., Angeli, R., Severini, C., Sannella, A. R., Bonini, P., Lucibello, M., Maggi, E., Garaci, E., Coluzzi, M., Cozzolino, F., Annunziato, F., Romagnani, S., Modiano, D. (2008). Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proc. Natl. Acad. Sci. USA 105: 646-651 [Abstract] [Full Text]  
• Chai, J.-G., Coe, D., Chen, D., Simpson, E., Dyson, J., Scott, D. (2008). In Vitro Expansion Improves In Vivo Regulation by CD4+CD25+ Regulatory T Cells. J. Immunol. 180: 858-869 [Abstract] [Full Text]  
• Li, S., Gowans, E. J., Chougnet, C., Plebanski, M., Dittmer, U. (2008). Natural Regulatory T Cells and Persistent Viral Infection. J. Virol. 82: 21-30 [Full Text]  
• Glick, A. B., Perez-Lorenzo, R., Mohammed, J. (2008). Context-dependent regulation of cutaneous immunological responses by TGF{beta}1 and its role in skin carcinogenesis. Carcinogenesis 29: 9-14 [Abstract] [Full Text]  
• Siewert, C., Lauer, U., Cording, S., Bopp, T., Schmitt, E., Hamann, A., Huehn, J. (2008). Experience-Driven Development: Effector/Memory-Like {alpha}E+Foxp3+ Regulatory T Cells Originate from Both Naive T Cells and Naturally Occurring Naive-Like Regulatory T Cells. J. Immunol. 180: 146-155 [Abstract] [Full Text]  
• Zarek, P. E., Huang, C.-T., Lutz, E. R., Kowalski, J., Horton, M. R., Linden, J., Drake, C. G., Powell, J. D. (2008). A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood 111: 251-259 [Abstract] [Full Text]  
• Xiao, S., Su, D.-m., Manley, N. R. (2007). Atypical Memory Phenotype T Cells with Low Homeostatic Potential and Impaired TCR Signaling and Regulatory T Cell Function in Foxn1{Delta}/{Delta} Mutant Mice. J. Immunol. 179: 8153-8163 [Abstract] [Full Text]  
• Yamazaki, S., Bonito, A. J., Spisek, R., Dhodapkar, M., Inaba, K., Steinman, R. M. (2007). Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 110: 4293-4302 [Abstract] [Full Text]  
• Lu, L.-F., Gavin, M. A., Rasmussen, J. P., Rudensky, A. Y. (2007). G Protein-Coupled Receptor 83 Is Dispensable for the Development and Function of Regulatory T Cells. Mol. Cell. Biol. 27: 8065-8072 [Abstract] [Full Text]  
• Pallandre, J.-R., Brillard, E., Crehange, G., Radlovic, A., Remy-Martin, J.-P., Saas, P., Rohrlich, P.-S., Pivot, X., Ling, X., Tiberghien, P., Borg, C. (2007). Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity. J. Immunol. 179: 7593-7604 [Abstract] [Full Text]  
• Ribot, J., Enault, G., Pilipenko, S., Huchenq, A., Calise, M., Hudrisier, D., Romagnoli, P., van Meerwijk, J. P. M. (2007). Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection. J. Immunol. 179: 6741-6748 [Abstract] [Full Text]  
• Alcorn, J. F., Rinaldi, L. M., Jaffe, E. F., van Loon, M., Bates, J. H. T., Janssen-Heininger, Y. M. W., Irvin, C. G. (2007). Transforming Growth Factor-beta1 Suppresses Airway Hyperresponsiveness in Allergic Airway Disease. Am. J. Respir. Crit. Care Med. 176: 974-982 [Abstract] [Full Text]  
• Wei, J., Duramad, O., Perng, O. A., Reiner, S. L., Liu, Y.-J., Qin, F. X.-F. (2007). Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 104: 18169-18174 [Abstract] [Full Text]  
• Feuerer, M., Jiang, W., Holler, P. D., Satpathy, A., Campbell, C., Bogue, M., Mathis, D., Benoist, C. (2007). Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 104: 18181-18186 [Abstract] [Full Text]  
• Haworth, O., Levy, B. D. (2007). Endogenous lipid mediators in the resolution of airway inflammation. Eur Respir J 30: 980-992 [Abstract] [Full Text]  
• Pritchard, D. I., Hooi, D. S. W., Brown, A., Bockarie, M. J., Caddick, R., Quinnell, R. J. (2007). Basophil Competence during Hookworm (Necator americanus) Infection. Am J Trop Med Hyg 77: 860-865 [Abstract] [Full Text]  
• Giorgini, A., Noble, A. (2007). Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts. J. Leukoc. Biol. 82: 1053-1061 [Abstract] [Full Text]  
• Chemnitz, J. M., Eggle, D., Driesen, J., Classen, S., Riley, J. L., Debey-Pascher, S., Beyer, M., Popov, A., Zander, T., Schultze, J. L. (2007). RNA fingerprints provide direct evidence for the inhibitory role of TGF{beta} and PD-1 on CD4+ T cells in Hodgkin lymphoma. Blood 110: 3226-3233 [Abstract] [Full Text]  
• Evans, H. G., Suddason, T., Jackson, I., Taams, L. S., Lord, G. M. (2007). Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc. Natl. Acad. Sci. USA 104: 17034-17039 [Abstract] [Full Text]  
• Li, R., Perez, N., Karumuthil-Melethil, S., Prabhakar, B. S., Holterman, M. J., Vasu, C. (2007). Enhanced Engagement of CTLA-4 Induces Antigen-Specific CD4+CD25+Foxp3+ and CD4+CD25 TGF-beta1+ Adaptive Regulatory T Cells. J. Immunol. 179: 5191-5203 [Abstract] [Full Text]  
• Tran, D. Q., Ramsey, H., Shevach, E. M. (2007). Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-{beta} dependent but does not confer a regulatory phenotype. Blood 110: 2983-2990 [Abstract] [Full Text]  
• Fineberg, S. E., Kawabata, T. T., Finco-Kent, D., Fountaine, R. J., Finch, G. L., Krasner, A. S. (2007). Immunological Responses to Exogenous Insulin. Endocr. Rev. 28: 625-652 [Abstract] [Full Text]  
• DiPaolo, R. J., Brinster, C., Davidson, T. S., Andersson, J., Glass, D., Shevach, E. M. (2007). Autoantigen-Specific TGFbeta-Induced Foxp3+ Regulatory T Cells Prevent Autoimmunity by Inhibiting Dendritic Cells from Activating Autoreactive T Cells. J. Immunol. 179: 4685-4693 [Abstract] [Full Text]  
• Kumpers, P., Gueler, F., Rong, S., Mengel, M., Tossidou, I., Peters, I., Haller, H., Schiffer, M. (2007). Leptin is a coactivator of TGF-beta in unilateral ureteral obstructive kidney disease. Am. J. Physiol. Renal Physiol. 293: F1355-F1362 [Abstract] [Full Text]  
• Vu, M. D., Xiao, X., Gao, W., Degauque, N., Chen, M., Kroemer, A., Killeen, N., Ishii, N., Chang Li, X. (2007). OX40 costimulation turns off Foxp3+ Tregs. Blood 110: 2501-2510 [Abstract] [Full Text]  
• Yang, Z.-Z., Novak, A. J., Ziesmer, S. C., Witzig, T. E., Ansell, S. M. (2007). CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells. Blood 110: 2537-2544 [Abstract] [Full Text]  
• Niedbala, W., Cai, B., Liu, H., Pitman, N., Chang, L., Liew, F. Y. (2007). Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40. Proc. Natl. Acad. Sci. USA 104: 15478-15483 [Abstract] [Full Text]  
• Fazilleau, N., Bachelez, H., Gougeon, M.-L., Viguier, M. (2007). Cutting Edge: Size and Diversity of CD4+CD25high Foxp3+ Regulatory T Cell Repertoire in Humans: Evidence for Similarities and Partial Overlapping with CD4+CD25 T Cells. J. Immunol. 179: 3412-3416 [Abstract] [Full Text]  
• Gaudreau, S., Guindi, C., Menard, M., Besin, G., Dupuis, G., Amrani, A. (2007). Granulocyte-Macrophage Colony-Stimulating Factor Prevents Diabetes Development in NOD Mice by Inducing Tolerogenic Dendritic Cells that Sustain the Suppressive Function of CD4+CD25+ Regulatory T Cells. J. Immunol. 179: 3638-3647 [Abstract] [Full Text]  
• Daley, S. R., Ma, J., Adams, E., Cobbold, S. P., Waldmann, H. (2007). A Key Role for TGF-beta Signaling to T Cells in the Long-Term Acceptance of Allografts. J. Immunol. 179: 3648-3654 [Abstract] [Full Text]  
• Gibson, H. M., Hedgcock, C. J., Aufiero, B. M., Wilson, A. J., Hafner, M. S., Tsokos, G. C., Wong, H. K. (2007). Induction of the CTLA-4 Gene in Human Lymphocytes Is Dependent on NFAT Binding the Proximal Promoter. J. Immunol. 179: 3831-3840 [Abstract] [Full Text]  
• Wong, J., Mathis, D., Benoist, C. (2007). TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 204: 2039-2045 [Abstract] [Full Text]  
• Hinz, S., Pagerols-Raluy, L., Oberg, H.-H., Ammerpohl, O., Grussel, S., Sipos, B., Grutzmann, R., Pilarsky, C., Ungefroren, H., Saeger, H.-D., Kloppel, G., Kabelitz, D., Kalthoff, H. (2007). Foxp3 Expression in Pancreatic Carcinoma Cells as a Novel Mechanism of Immune Evasion in Cancer. Cancer Res. 67: 8344-8350 [Abstract] [Full Text]  
• Behrens, F., Himsel, A., Rehart, S., Stanczyk, J., Beutel, B., Zimmermann, S. Y, Koehl, U., Moller, B., Gay, S., Kaltwasser, J. P, Pfeilschifter, J. M, Radeke, H. H (2007). Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis 66: 1151-1156 [Abstract] [Full Text]  
• Reichardt, P., Dornbach, B., Rong, S., Beissert, S., Gueler, F., Loser, K., Gunzer, M. (2007). Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood 110: 1519-1529 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS