Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Reinhardt, R. L. Articles by Jenkins, M. K. Search for Related Content PubMed PubMed Citation Articles by Reinhardt, R. L. Articles by Jenkins, M. K. Social Bookmarking                      What's this?

¹ Department of Microbiology and the Center for Immunology, University of Minnesota, Minneapolis, MN 55455
² Departments of Genomics and Pathobiology, University of Alabama at Birmingham, Birmingham, AL 35294
³ Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294

Address correspondence to Marc K. Jenkins, University of Minnesota, Center for Immunology, MMC 334, 420 Delaware St. S.E., Minneapolis, MN 55455. Phone: 612-626-2715; Fax: 612-625-2199; E-mail: marcj{at}mail.ahc.umn.edu

The migration of antigen-specific T cells to nonlymphoid tissues is thought to be important for the elimination of foreign antigens from the body. However, recent results showing the migration of activated T cells into many nonlymphoid tissues raised the possibility that antigen-specific T cells do not migrate preferentially to nonlymphoid tissues containing antigen. We addressed this question by tracking antigen-specific CD4 T cells in the whole body after a localized subcutaneous antigen injection. Antigen-specific CD4 T cells proliferated in the skin-draining lymph nodes and the cells that underwent the most cell divisions acquired the ability to bind to CD62P. As time passed, CD62P-binding antigen-specific CD4 T cells with interferon production potential accumulated preferentially at the site of antigen injection but only in recipients that expressed CD62E. Surprisingly, these T cells did not proliferate in the injection site despite showing evidence of more cell divisions than the T cells in the draining lymph nodes. The results suggest that the most divided effector CD4 T cells from the lymph nodes enter the site of antigen deposition via recognition of CD62E on blood vessels and are retained there in a nonproliferative state via recognition of peptide–major histocompatibility complex II molecules.

Key Words: antigen-specific • CD4 • T cell • migration • selectin

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Edgtton, K. L., Kausman, J. Y., Li, M., O'Sullivan, K., Lo, C., Hutchinson, P., Yagita, H., Holdsworth, S. R., Kitching, A. R. (2008). Intrarenal Antigens Activate CD4+ Cells via Co-stimulatory Signals from Dendritic Cells. J. Am. Soc. Nephrol. 19: 515-526 [Abstract] [Full Text]  
• McLachlan, J. B., Jenkins, M. K. (2007). Parker B. Francis Lectureship. Migration and Accumulation of Effector CD4+ T Cells in Nonlymphoid Tissues. Proc Am Thorac Soc 4: 439-442 [Abstract] [Full Text]  
• Kallinich, T., Beier, K. C., Wahn, U., Stock, P., Hamelmann, E. (2007). T-cell co-stimulatory molecules: their role in allergic immune reactions. Eur Respir J 29: 1246-1255 [Abstract] [Full Text]  
• Agrewala, J. N., Brown, D. M., Lepak, N. M., Duso, D., Huston, G., Swain, S. L. (2007). Unique Ability of Activated CD4+ T Cells but Not Rested Effectors to Migrate to Non-lymphoid Sites in the Absence of Inflammation. J. Biol. Chem. 282: 6106-6115 [Abstract] [Full Text]  
• Co, D. O., Hogan, L. H., Karman, J., Heninger, E., Vang, S., Wells, K., Kawaoka, Y., Sandor, M. (2006). Interactions between T Cells Responding to Concurrent Mycobacterial and Influenza Infections. J. Immunol. 177: 8456-8465 [Abstract] [Full Text]  
• Lambe, T., Leung, J. C. H., Bouriez-Jones, T., Silver, K., Makinen, K., Crockford, T. L., Ferry, H., Forrester, J. V., Cornall, R. J. (2006). CD4 T Cell-Dependent Autoimmunity against a Melanocyte Neoantigen Induces Spontaneous Vitiligo and Depends upon Fas-Fas Ligand Interactions.. J. Immunol. 177: 3055-3062 [Abstract] [Full Text]  
• Li, M., O'Sullivan, K. M., Jones, L. K., Semple, T., Kumanogoh, A., Kikutani, H., Holdsworth, S. R., Kitching, A. R. (2006). CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis.. J. Immunol. 177: 3406-3412 [Abstract] [Full Text]  
• Spargo, L. D., Cleland, L. G, Cockshell, M. P, Mayrhofer, G. (2006). Recruitment and proliferation of CD4+ T cells in synovium following adoptive transfer of adjuvant-induced arthritis. Int Immunol 18: 897-910 [Abstract] [Full Text]  
• Joncker, N. T., Helft, J., Jacquet, A., Premel, V., Lantz, O. (2006). Intratumor CD4 T-cell accumulation requires stronger priming than for expansion and lymphokine secretion.. Cancer Res. 66: 5443-5451 [Abstract] [Full Text]  
• Catron, D. M., Rusch, L. K., Hataye, J., Itano, A. A., Jenkins, M. K. (2006). CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells. J. Exp. Med. 203: 1045-1054 [Abstract] [Full Text]  
• Ling, C., Sandor, M., Suresh, M., Fabry, Z. (2006). Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS. J. Neurosci. 26: 731-741 [Abstract] [Full Text]  
• Yang, J., Huck, S. P., McHugh, R. S., Hermans, I. F., Ronchese, F. (2006). Perforin-dependent elimination of dendritic cells regulates the expansion of antigen-specific CD8+ T cells in vivo. Proc. Natl. Acad. Sci. USA 103: 147-152 [Abstract] [Full Text]  
• Debes, G. F., Dahl, M. E., Mahiny, A. J., Bonhagen, K., Campbell, D. J., Siegmund, K., Erb, K. J., Lewis, D. B., Kamradt, T., Hamann, A. (2006). Chemotactic Responses of IL-4-, IL-10-, and IFN-{gamma}-Producing CD4+ T Cells Depend on Tissue Origin and Microbial Stimulus. J. Immunol. 176: 557-566 [Abstract] [Full Text]  
• Georas, S. N., Guo, J., De Fanis, U., Casolaro, V. (2005). T-helper cell type-2 regulation in allergic disease. Eur Respir J 26: 1119-1137 [Abstract] [Full Text]  
• Mangan, P. R., O'Quinn, D., Harrington, L., Bonder, C. S., Kubes, P., Kucik, D. F., Bullard, D. C., Weaver, C. T. (2005). Both Th1 and Th2 Cells Require P-Selectin Glycoprotein Ligand-1 for Optimal Rolling on Inflamed Endothelium. Am. J. Pathol. 167: 1661-1675 [Abstract] [Full Text]  
• Mohrs, K., Harris, D. P., Lund, F. E., Mohrs, M. (2005). Systemic Dissemination and Persistence of Th2 and Type 2 Cells in Response to Infection with a Strictly Enteric Nematode Parasite. J. Immunol. 175: 5306-5313 [Abstract] [Full Text]  
• Prlic, M., Gibbs, J., Jameson, S. C. (2005). Characteristics of NK Cell Migration Early after Vaccinia Infection. J. Immunol. 175: 2152-2157 [Abstract] [Full Text]  
• Gough, M., Crittenden, M., Thanarajasingam, U., Sanchez-Perez, L., Thompson, J., Jevremovic, D., Vile, R. (2005). Gene Therapy to Manipulate Effector T Cell Trafficking to Tumors for Immunotherapy. J. Immunol. 174: 5766-5773 [Abstract] [Full Text]  
• Thorstenson, K. M., Herzovi, L., Khoruts, A. (2005). A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25+CD4 T cells in vivo. Int Immunol 17: 335-342 [Abstract] [Full Text]  
• Syrbe, U., Jennrich, S., Schottelius, A., Richter, A., Radbruch, A., Hamann, A. (2004). Differential regulation of P-selectin ligand expression in naive versus memory CD4+ T cells: evidence for epigenetic regulation of involved glycosyltransferase genes. Blood 104: 3243-3248 [Abstract] [Full Text]  
• Georas, S. N. (2004). Inhaled Glucocorticoids, Lymphocytes, and Dendritic Cells in Asthma and Obstructive Lung Diseases. Proc Am Thorac Soc 1: 215-221 [Abstract] [Full Text]  
• Kandula, S., Abraham, C. (2004). LFA-1 on CD4+ T Cells Is Required for Optimal Antigen-Dependent Activation In Vivo. J. Immunol. 173: 4443-4451 [Abstract] [Full Text]  
• Anderson, M. J., Fritsche, K. L. (2004). Dietary Polyunsaturated Fatty Acids Modulate In Vivo, Antigen-Driven CD4+ T-Cell Proliferation in Mice. J. Nutr. 134: 1978-1983 [Abstract] [Full Text]  
• Debes, G. F., Bonhagen, K., Wolff, T., Kretschmer, U., Krautwald, S., Kamradt, T., Hamann, A. (2004). CC Chemokine Receptor 7 Expression by Effector/Memory CD4+ T Cells Depends on Antigen Specificity and Tissue Localization during Influenza A Virus Infection. J. Virol. 78: 7528-7535 [Abstract] [Full Text]  
• Srinivasan, A., Foley, J., McSorley, S. J. (2004). Massive Number of Antigen-Specific CD4 T Cells during Vaccination with Live Attenuated Salmonella Causes Interclonal Competition. J. Immunol. 172: 6884-6893 [Abstract] [Full Text]  
• Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., Beverley, P. C.L., Rustin, M. H.A., Akbar, A. N. (2004). Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo. J. Exp. Med. 199: 1433-1443 [Abstract] [Full Text]  
• Morimoto, M., Morimoto, M., Whitmire, J., Xiao, S., Anthony, R. M., Mirakami, H., Star, R. A., Urban, J. F. Jr, Gause, W. C. (2004). Peripheral CD4 T Cells Rapidly Accumulate at the Host:Parasite Interface during an Inflammatory Th2 Memory Response. J. Immunol. 172: 2424-2430 [Abstract] [Full Text]  
• Lemos, M. P., Fan, L., Lo, D., Laufer, T. M. (2003). CD8{alpha}+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity. J. Immunol. 171: 5077-5084 [Abstract] [Full Text]  
• Zaph, C., Scott, P. (2003). Th1 Cell-Mediated Resistance to Cutaneous Infection with Leishmania major Is Independent of P- and E-Selectins. J. Immunol. 171: 4726-4732 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS