Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lasagni, L. Articles by Romagnani, P. Search for Related Content PubMed PubMed Citation Articles by Lasagni, L. Articles by Romagnani, P. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Nucleotide OMIM Protein UniGene Substance via MeSH Social Bookmarking                      What's this?

¹ Department of Clinical Pathophysiology, University of Florence, Florence 50139, Italy
² Department of Internal Medicine, University of Florence, Florence 50139, Italy

Address correspondence to Paola Romagnani, Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. Phone: 390554271483; Fax: 390554271371; E-mail: p.romagnani{at}dfc.unifi.it

The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth. These multiple activities are apparently mediated by a unique G protein–coupled receptor, termed CXCR3. The chemokine CXCL4/PF4 shares several activities with CXCL9, CXCL10, and CXCL11, including a powerful angiostatic effect, but its specific receptor is still unknown. Here, we describe a distinct, previously unrecognized receptor named CXCR3-B, derived from an alternative splicing of the CXCR3 gene that mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4.

Human microvascular endothelial cell line-1 (HMEC-1), transfected with either the known CXCR3 (renamed CXCR3-A) or CXCR3-B, bound CXCL9, CXCL10, and CXCL11, whereas CXCL4 showed high affinity only for CXCR3-B. Overexpression of CXCR3-A induced an increase of survival, whereas overexpression of CXCR3-B dramatically reduced DNA synthesis and up-regulated apoptotic HMEC-1 death through activation of distinct signal transduction pathways. Remarkably, primary cultures of human microvascular endothelial cells, whose growth is inhibited by CXCL9, CXCL10, CXCL11, and CXCL4, expressed CXCR3-B, but not CXCR3-A. Finally, monoclonal antibodies raised to selectively recognize CXCR3-B reacted with endothelial cells from neoplastic tissues, providing evidence that CXCR3-B is also expressed in vivo and may account for the angiostatic effects of CXC chemokines.

Key Words: CXCR3-B • CXCR3-A • angiogenesis • chemokines • chemokines receptor

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Yates, C. C., Whaley, D., Y-Chen, A., Kulesekaran, P., Hebda, P. A., Wells, A. (2008). ELR-Negative CXC Chemokine CXCL11 (IP-9/I-TAC) Facilitates Dermal and Epidermal Maturation during Wound Repair. Am. J. Pathol. 173: 643-652 [Abstract] [Full Text]  
• Ji, R., Lee, C. M., Gonzales, L. W., Yang, Y., Aksoy, M. O., Wang, P., Brailoiu, E., Dun, N., Hurford, M. T., Kelsen, S. G. (2008). Human type II pneumocyte chemotactic responses to CXCR3 activation are mediated by splice variant A. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L1187-L1196 [Abstract] [Full Text]  
• Li, N. (2008). Platelet-lymphocyte cross-talk. J. Leukoc. Biol. 83: 1069-1078 [Abstract] [Full Text]  
• Mueller, A., Meiser, A., McDonagh, E. M., Fox, J. M., Petit, S. J., Xanthou, G., Williams, T. J., Pease, J. E. (2008). CXCL4-induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3. J. Leukoc. Biol. 83: 875-882 [Abstract] [Full Text]  
• Woller, G., Brandt, E., Mittelstadt, J., Rybakowski, C., Petersen, F. (2008). Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals. J. Leukoc. Biol. 83: 936-945 [Abstract] [Full Text]  
• Mazzinghi, B., Ronconi, E., Lazzeri, E., Sagrinati, C., Ballerini, L., Angelotti, M. L., Parente, E., Mancina, R., Netti, G. S., Becherucci, F., Gacci, M., Carini, M., Gesualdo, L., Rotondi, M., Maggi, E., Lasagni, L., Serio, M., Romagnani, S., Romagnani, P. (2008). Essential but differential role for CXCR4 and CXCR7 in the therapeutic homingof human renal progenitor cells. J. Exp. Med. 205: 479-490 [Abstract] [Full Text]  
• Kim, J. Y., Song, H.-J., Lim, H.-J., Shin, M.-G., Kim, J. S., Kim, H.-J., Kim, B. Y., Lee, S.-w. (2008). Platelet Factor-4 Is an Indicator of Blood Count Recovery in Acute Myeloid Leukemia Patients in Complete Remission. Mol. Cell. Proteomics 7: 431-441 [Abstract] [Full Text]  
• Matsuda, A., Fukuda, S., Matsumoto, K., Saito, H. (2008). Th1/Th2 Cytokines Reciprocally Regulate In Vitro Pulmonary Angiogenesis via CXC Chemokine Synthesis. Am. J. Respir. Cell Mol. Bio. 38: 168-175 [Abstract] [Full Text]  
• Cabrelle, A., Dell'Aica, I., Melchiori, L., Carraro, S., Brunetta, E., Niero, R., Scquizzato, E., D'Intino, G., Calza, L., Garbisa, S., Agostini, C. (2008). Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease. J. Leukoc. Biol. 83: 212-219 [Abstract] [Full Text]  
• Lazzeri, E., Crescioli, C., Ronconi, E., Mazzinghi, B., Sagrinati, C., Netti, G. S., Angelotti, M. L., Parente, E., Ballerini, L., Cosmi, L., Maggi, L., Gesualdo, L., Rotondi, M., Annunziato, F., Maggi, E., Lasagni, L., Serio, M., Romagnani, S., Vannelli, G. B., Romagnani, P. (2007). Regenerative Potential of Embryonic Renal Multipotent Progenitors in Acute Renal Failure. J. Am. Soc. Nephrol. 18: 3128-3138 [Abstract] [Full Text]  
• Nabah, Y. N. A., Losada, M., Estelles, R., Mateo, T., Company, C., Piqueras, L., Lopez-Gines, C., Sarau, H., Cortijo, J., Morcillo, E. J., Jose, P. J., Sanz, M.-J. (2007). CXCR2 Blockade Impairs Angiotensin II Induced CC Chemokine Synthesis and Mononuclear Leukocyte Infiltration. Arterioscler. Thromb. Vasc. Bio. 27: 2370-2376 [Abstract] [Full Text]  
• Winter, D., Moser, J., Kriehuber, E., Wiesner, C., Knobler, R., Trautinger, F., Bombosi, P., Stingl, G., Petzelbauer, P., Rot, A., Maurer, D. (2007). Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients. J. Immunol. 179: 4272-4282 [Abstract] [Full Text]  
• Kasper, B., Brandt, E., Brandau, S., Petersen, F. (2007). Platelet Factor 4 (CXC Chemokine Ligand 4) Differentially Regulates Respiratory Burst, Survival, and Cytokine Expression of Human Monocytes by Using Distinct Signaling Pathways. J. Immunol. 179: 2584-2591 [Abstract] [Full Text]  
• Rotondi, M., Chiovato, L., Romagnani, S., Serio, M., Romagnani, P. (2007). Role of Chemokines in Endocrine Autoimmune Diseases. Endocr. Rev. 28: 492-520 [Abstract] [Full Text]  
• Proost, P., Mortier, A., Loos, T., Vandercappellen, J., Gouwy, M., Ronsse, I., Schutyser, E., Put, W., Parmentier, M., Struyf, S., Van Damme, J. (2007). Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood 110: 37-44 [Abstract] [Full Text]  
• Struyf, S., Burdick, M. D., Peeters, E., Van den Broeck, K., Dillen, C., Proost, P., Van Damme, J., Strieter, R. M. (2007). Platelet Factor-4 Variant Chemokine CXCL4L1 Inhibits Melanoma and Lung Carcinoma Growth and Metastasis by Preventing Angiogenesis. Cancer Res. 67: 5940-5948 [Abstract] [Full Text]  
• Lasagni, L., Grepin, R., Mazzinghi, B., Lazzeri, E., Meini, C., Sagrinati, C., Liotta, F., Frosali, F., Ronconi, E., Alain-Courtois, N., Ballerini, L., Netti, G. S., Maggi, E., Annunziato, F., Serio, M., Romagnani, S., Bikfalvi, A., Romagnani, P. (2007). PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood 109: 4127-4134 [Abstract] [Full Text]  
• Zipin-Roitman, A., Meshel, T., Sagi-Assif, O., Shalmon, B., Avivi, C., Pfeffer, R. M., Witz, I. P., Ben-Baruch, A. (2007). CXCL10 Promotes Invasion-Related Properties in Human Colorectal Carcinoma Cells. Cancer Res. 67: 3396-3405 [Abstract] [Full Text]  
• Indraccolo, S., Pfeffer, U., Minuzzo, S., Esposito, G., Roni, V., Mandruzzato, S., Ferrari, N., Anfosso, L., Dell'Eva, R., Noonan, D. M., Chieco-Bianchi, L., Albini, A., Amadori, A. (2007). Identification of Genes Selectively Regulated by IFNs in Endothelial Cells. J. Immunol. 178: 1122-1135 [Abstract] [Full Text]  
• von Hundelshausen, P., Weber, C. (2007). Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease. Circ. Res. 100: 27-40 [Abstract] [Full Text]  
• Hirota, Y., Osuga, Y., Koga, K., Yoshino, O., Hirata, T., Morimoto, C., Harada, M., Takemura, Y., Nose, E., Yano, T., Tsutsumi, O., Taketani, Y. (2006). The Expression and Possible Roles of Chemokine CXCL11 and Its Receptor CXCR3 in the Human Endometrium. J. Immunol. 177: 8813-8821 [Abstract] [Full Text]  
• Datta, D., Flaxenburg, J. A., Laxmanan, S., Geehan, C., Grimm, M., Waaga-Gasser, A. M., Briscoe, D. M., Pal, S. (2006). Ras-induced Modulation of CXCL10 and Its Receptor Splice Variant CXCR3-B in MDA-MB-435 and MCF-7 Cells: Relevance for the Development of Human Breast Cancer. Cancer Res. 66: 9509-9518 [Abstract] [Full Text]  
• Sagrinati, C., Netti, G. S., Mazzinghi, B., Lazzeri, E., Liotta, F., Frosali, F., Ronconi, E., Meini, C., Gacci, M., Squecco, R., Carini, M., Gesualdo, L., Francini, F., Maggi, E., Annunziato, F., Lasagni, L., Serio, M., Romagnani, S., Romagnani, P. (2006). Isolation and Characterization of Multipotent Progenitor Cells from the Bowman's Capsule of Adult Human Kidneys. J. Am. Soc. Nephrol. 17: 2443-2456 [Abstract] [Full Text]  
• Shahabuddin, S., Ji, R., Wang, P., Brailoiu, E., Dun, N., Yang, Y., Aksoy, M. O., Kelsen, S. G. (2006). CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways. Am. J. Physiol. Cell Physiol. 291: C34-C39 [Abstract] [Full Text]  
• Aksoy, M. O., Yang, Y., Ji, R., Reddy, P. J., Shahabuddin, S., Litvin, J., Rogers, T. J., Kelsen, S. G. (2006). CXCR3 surface expression in human airway epithelial cells: cell cycle dependence and effect on cell proliferation. Am. J. Physiol. Lung Cell. Mol. Physiol. 290: L909-L918 [Abstract] [Full Text]  
• Liu, L., Huang, D., Matsui, M., He, T. T., Hu, T., DeMartino, J., Lu, B., Gerard, C., Ransohoff, R. M. (2006). Severe Disease, Unaltered Leukocyte Migration, and Reduced IFN-{gamma} Production in CXCR3-/- Mice with Experimental Autoimmune Encephalomyelitis. J. Immunol. 176: 4399-4409 [Abstract] [Full Text]  
• Bodnar, R. J., Yates, C. C., Wells, A. (2006). IP-10 Blocks Vascular Endothelial Growth Factor-Induced Endothelial Cell Motility and Tube Formation via Inhibition of Calpain. Circ. Res. 98: 617-625 [Abstract] [Full Text]  
• Korherr, C., Gille, H., Schafer, R., Koenig-Hoffmann, K., Dixelius, J., Egland, K. A., Pastan, I., Brinkmann, U. (2006). Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway.. Proc. Natl. Acad. Sci. USA 103: 4240-4245 [Abstract] [Full Text]  
• Boulday, G., Haskova, Z., Reinders, M. E. J., Pal, S., Briscoe, D. M. (2006). Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-{gamma}-Inducible Protein of 10 kDa In Vitro and In Vivo.. J. Immunol. 176: 3098-3107 [Abstract] [Full Text]  
• Kasper, B., Brandt, E., Ernst, M., Petersen, F. (2006). Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases. Blood 107: 1768-1775 [Abstract] [Full Text]  
• Pende, D., Castriconi, R., Romagnani, P., Spaggiari, G. M., Marcenaro, S., Dondero, A., Lazzeri, E., Lasagni, L., Martini, S., Rivera, P., Capobianco, A., Moretta, L., Moretta, A., Bottino, C. (2006). Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 107: 2030-2036 [Abstract] [Full Text]  
• Sfriso, P., Oliviero, F., Calabrese, F., Miorin, M., Facco, M., Contri, A., Cabrelle, A., Baesso, I., Cozzi, F., Andretta, M., Cassatella, M. A., Fiocco, U., Todesco, S., Konttinen, Y. T., Punzi, L., Agostini, C. (2006). Epithelial CXCR3-B Regulates Chemokines Bioavailability in Normal, but Not in Sjogren's Syndrome, Salivary Glands. J. Immunol. 176: 2581-2589 [Abstract] [Full Text]  
• Ottersbach, K., Mclean, J., Isaacs, N. W., Graham, G. J. (2006). A310 helical turn is essential for the proliferation-inhibiting properties of macrophage inflammatory protein-1 alpha (CCL3). Blood 107: 1284-1291 [Abstract] [Full Text]  
• Pan, J., Burdick, M. D., Belperio, J. A., Xue, Y. Y., Gerard, C., Sharma, S., Dubinett, S. M., Strieter, R. M. (2006). CXCR3/CXCR3 Ligand Biological Axis Impairs RENCA Tumor Growth by a Mechanism of Immunoangiostasis. J. Immunol. 176: 1456-1464 [Abstract] [Full Text]  
• Pignatti, P., Brunetti, G., Moretto, D., Yacoub, M.-R., Fiori, M., Balbi, B., Balestrino, A., Cervio, G., Nava, S., Moscato, G. (2006). Role of the Chemokine Receptors CXCR3 and CCR4 in Human Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 173: 310-317 [Abstract] [Full Text]  
• Han, G. D., Suzuki, K., Koike, H., Suzuki, K., Yoneyama, H., Narumi, S., Shimizu, F., Kawachi, H. (2006). IFN-Inducible Protein-10 Plays a Pivotal Role in Maintaining Slit-Diaphragm Function by Regulating Podocyte Cell-Cycle Balance. J. Am. Soc. Nephrol. 17: 442-453 [Abstract] [Full Text]  
• Feldman, E. D., Weinreich, D. M., Carroll, N. M., Burness, M. L., Feldman, A. L., Turner, E., Xu, H., Alexander, H. R. Jr. (2006). Interferon {gamma}-Inducible Protein 10 Selectively Inhibits Proliferation and Induces Apoptosis in Endothelial Cells. Ann. Surg. Oncol. 13: 125-133 [Abstract] [Full Text]  
• Debes, G. F., Dahl, M. E., Mahiny, A. J., Bonhagen, K., Campbell, D. J., Siegmund, K., Erb, K. J., Lewis, D. B., Kamradt, T., Hamann, A. (2006). Chemotactic Responses of IL-4-, IL-10-, and IFN-{gamma}-Producing CD4+ T Cells Depend on Tissue Origin and Microbial Stimulus. J. Immunol. 176: 557-566 [Abstract] [Full Text]  
• Shigihara, T., Shimada, A., Oikawa, Y., Yoneyama, H., Kanazawa, Y., Okubo, Y., Matsushima, K., Yamato, E., Miyazaki, J.-i., Kasuga, A., Saruta, T., Narumi, S. (2005). CXCL10 DNA Vaccination Prevents Spontaneous Diabetes through Enhanced {beta} Cell Proliferation in NOD Mice. J. Immunol. 175: 8401-8408 [Abstract] [Full Text]  
• Kouroumalis, A., Nibbs, R. J., Aptel, H., Wright, K. L., Kolios, G., Ward, S. G. (2005). The Chemokines CXCL9, CXCL10, and CXCL11 Differentially Stimulate G{alpha}i-Independent Signaling and Actin Responses in Human Intestinal Myofibroblasts. J. Immunol. 175: 5403-5411 [Abstract] [Full Text]  
• Romagnani, P., Annunziato, F., Liotta, F., Lazzeri, E., Mazzinghi, B., Frosali, F., Cosmi, L., Maggi, L., Lasagni, L., Scheffold, A., Kruger, M., Dimmeler, S., Marra, F., Gensini, G., Maggi, E., Romagnani, S. (2005). CD14+CD34low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors. Circ. Res. 97: 314-322 [Abstract] [Full Text]  
• Howard, O. M. Z., Dong, H. F., Su, S. B., Caspi, R. R., Chen, X., Plotz, P., Oppenheim, J. J. (2005). Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Blood 105: 4207-4214 [Abstract] [Full Text]  
• Feferman, T., Maiti, P. K., Berrih-Aknin, S., Bismuth, J., Bidault, J., Fuchs, S., Souroujon, M. C. (2005). Overexpression of IFN-Induced Protein 10 and Its Receptor CXCR3 in Myasthenia Gravis. J. Immunol. 174: 5324-5331 [Abstract] [Full Text]  
• Weber, C. (2005). Platelets and Chemokines in Atherosclerosis: Partners in Crime. Circ. Res. 96: 612-616 [Abstract] [Full Text]  
• Waeckel, L., Mallat, Z., Potteaux, S., Combadiere, C., Clergue, M., Duriez, M., Bao, L., Gerard, C., Rollins, B. J., Tedgui, A., Levy, B. I., Silvestre, J.-S. (2005). Impairment in Postischemic Neovascularization in Mice Lacking the CXC Chemokine Receptor 3. Circ. Res. 96: 576-582 [Abstract] [Full Text]  
• Satish, L., Blair, H. C., Glading, A., Wells, A. (2005). Interferon-Inducible Protein 9 (CXCL11)-Induced Cell Motility in Keratinocytes Requires Calcium Flux-Dependent Activation of {micro}-Calpain. Mol. Cell. Biol. 25: 1922-1941 [Abstract] [Full Text]  
• Liu, C. Y., Battaglia, M., Lee, S. H., Sun, Q.-H., Aster, R. H., Visentin, G. P. (2005). Platelet Factor 4 Differentially Modulates CD4+CD25+ (Regulatory) versus CD4+CD25- (Nonregulatory) T Cells. J. Immunol. 174: 2680-2686 [Abstract] [Full Text]  
• Burdick, M. D., Murray, L. A., Keane, M. P., Xue, Y. Y., Zisman, D. A., Belperio, J. A., Strieter, R. M. (2005). CXCL11 Attenuates Bleomycin-induced Pulmonary Fibrosis via Inhibition of Vascular Remodeling. Am. J. Respir. Crit. Care Med. 171: 261-268 [Abstract] [Full Text]  
• von Hundelshausen, P., Koenen, R. R., Sack, M., Mause, S. F., Adriaens, W., Proudfoot, A. E. I., Hackeng, T. M., Weber, C. (2005). Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood 105: 924-930 [Abstract] [Full Text]  
• Croce, M., Meazza, R., Orengo, A. M., Radic', L., De Giovanni, B., Gambini, C., Carlini, B., Pistoia, V., Mortara, L., Accolla, R. S., Corrias, M. V., Ferrini, S. (2005). Sequential Immunogene Therapy with Interleukin-12- and Interleukin-15-Engineered Neuroblastoma Cells Cures Metastatic Disease in Syngeneic Mice. Clin. Cancer Res. 11: 735-742 [Abstract] [Full Text]  
• Kohrgruber, N., Groger, M., Meraner, P., Kriehuber, E., Petzelbauer, P., Brandt, S., Stingl, G., Rot, A., Maurer, D. (2004). Plasmacytoid Dendritic Cell Recruitment by Immobilized CXCR3 Ligands. J. Immunol. 173: 6592-6602 [Abstract] [Full Text]  
• Morimoto, J., Yoneyama, H., Shimada, A., Shigihara, T., Yamada, S., Oikawa, Y., Matsushima, K., Saruta, T., Narumi, S. (2004). CXC Chemokine Ligand 10 Neutralization Suppresses the Occurrence of Diabetes in Nonobese Diabetic Mice through Enhanced {beta} Cell Proliferation without Affecting Insulitis. J. Immunol. 173: 7017-7024 [Abstract] [Full Text]  
• Liu, C. Y., Yuan, G., Sun, Q.-H., Visentin, G. P. (2004). A Spliced Variant of CXCR3 (CXCR3B) Is Differentially Expressed on CD4+CD25+ Regulatory vs. CD4+CD25- Non-Regulatory T Cells Exposed to Platelet Factor 4 (PF4).. ASH ANNUAL MEETING ABSTRACTS 104: 3021-3021 [Abstract]  
• Shellenberger, T. D., Wang, M., Gujrati, M., Jayakumar, A., Strieter, R. M., Burdick, M. D., Ioannides, C. G., Efferson, C. L., El-Naggar, A. K., Roberts, D., Clayman, G. L., Frederick, M. J. (2004). BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells. Cancer Res. 64: 8262-8270 [Abstract] [Full Text]  
• Ehlert, J. E., Addison, C. A., Burdick, M. D., Kunkel, S. L., Strieter, R. M. (2004). Identification and Partial Characterization of a Variant of Human CXCR3 Generated by Posttranscriptional Exon Skipping. J. Immunol. 173: 6234-6240 [Abstract] [Full Text]  
• Eslin, D. E., Zhang, C., Samuels, K. J., Rauova, L., Zhai, L., Niewiarowski, S., Cines, D. B., Poncz, M., Kowalska, M. A. (2004). Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood 104: 3173-3180 [Abstract] [Full Text]  
• Antonelli, A., Rotondi, M., Fallahi, P., Romagnani, P., Ferrari, S. M., Buonamano, A., Ferrannini, E., Serio, M. (2004). High Levels of Circulating CXC Chemokine Ligand 10 Are Associated with Chronic Autoimmune Thyroiditis and Hypothyroidism. J. Clin. Endocrinol. Metab. 89: 5496-5499 [Abstract] [Full Text]  
• Weber, C., Schober, A., Zernecke, A. (2004). Chemokines: Key Regulators of Mononuclear Cell Recruitment in Atherosclerotic Vascular Disease. Arterioscler. Thromb. Vasc. Bio. 24: 1997-2008 [Abstract] [Full Text]  
• Moser, B, Willimann, K (2004). Chemokines: role in inflammation and immune surveillance. Ann Rheum Dis 63: ii84-ii89 [Abstract] [Full Text]  
• Struyf, S., Burdick, M. D., Proost, P., Van Damme, J., Strieter, R. M. (2004). Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis. Circ. Res. 95: 855-857 [Abstract] [Full Text]  
• Kelsen, S. G., Aksoy, M. O., Yang, Y., Shahabuddin, S., Litvin, J., Safadi, F., Rogers, T. J. (2004). The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L584-L591 [Abstract] [Full Text]  
• Adams, S., Miller, G. T., Jesson, M. I., Watanabe, T., Jones, B., Wallner, B. P. (2004). PT-100, a Small Molecule Dipeptidyl Peptidase Inhibitor, Has Potent Antitumor Effects and Augments Antibody-Mediated Cytotoxicity via a Novel Immune Mechanism. Cancer Res. 64: 5471-5480 [Abstract] [Full Text]  
• Pervushina, O., Scheuerer, B., Reiling, N., Behnke, L., Schroder, Jens.-M., Kasper, B., Brandt, E., Bulfone-Paus, S., Petersen, F. (2004). Platelet Factor 4/CXCL4 Induces Phagocytosis and the Generation of Reactive Oxygen Metabolites in Mononuclear Phagocytes Independently of Gi Protein Activation or Intracellular Calcium Transients. J. Immunol. 173: 2060-2067 [Abstract] [Full Text]  
• Strieter, R. M., Starko, K. M., Enelow, R. I., Noth, I., Valentine, V. G., the other members of the Idiopathic Pulmonary Fibr, (2004). Effects of Interferon-{gamma} 1b on Biomarker Expression in Patients with Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 170: 133-140 [Abstract] [Full Text]  
• Gouwy, M., Struyf, S., Catusse, J., Proost, P., Van Damme, J. (2004). Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration. J. Leukoc. Biol. 76: 185-194 [Abstract] [Full Text]  
• Proost, P., Verpoest, S., de Borne, K. V., Schutyser, E., Struyf, S., Put, W., Ronsse, I., Grillet, B., Opdenakker, G., Damme, J. V. (2004). Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-{gamma} in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids. J. Leukoc. Biol. 75: 777-784 [Abstract] [Full Text]  
• Hensbergen, P. J., Verzijl, D., Balog, C. I. A., Dijkman, R., van der Schors, R. C., van der Raaij-Helmer, E. M. H., van der Plas, M. J. A., Leurs, R., Deelder, A. M., Smit, M. J., Tensen, C. P. (2004). Furin Is a Chemokine-modifying Enzyme: IN VITRO AND IN VIVO PROCESSING OF CXCL10 GENERATES A C-TERMINALLY TRUNCATED CHEMOKINE RETAINING FULL ACTIVITY. J. Biol. Chem. 279: 13402-13411 [Abstract] [Full Text]  
• Segerer, S., Banas, B., Wornle, M., Schmid, H., Cohen, C. D., Kretzler, M., Mack, M., Kiss, E., Nelson, P. J., Schlondorff, D., Grone, H.-J. (2004). CXCR3 Is Involved in Tubulointerstitial Injury in Human Glomerulonephritis. Am. J. Pathol. 164: 635-649 [Abstract] [Full Text]  
• Mitola, S., Strasly, M., Prato, M., Ghia, P., Bussolino, F. (2003). IL-12 Regulates an Endothelial Cell-Lymphocyte Network: Effect on Metalloproteinase-9 Production. J. Immunol. 171: 3725-3733 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS