Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 128K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Boonstra, A. Articles by O'Garra, A. Search for Related Content PubMed PubMed Citation Articles by Boonstra, A. Articles by O'Garra, A. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Social Bookmarking                      What's this?

André Boonstra¹, Carine Asselin-Paturel², Michel Gilliet³, Chad Crain³, Giorgio Trinchieri², Yong-Jun Liu³ and Anne O'Garra¹

¹ Division of Immunoregulation, The National Institute for Medical Research (NIMR), NW7 1AA London, United Kingdom
² Laboratory for Immunological Research, Schering-Plough, 69571 Dardilly, France
³ Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304

Address correspondence to Anne O'Garra or Andre Boonstra, Division of Immunoregulation, NIMR, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom. Phone: 44-208-959-3666; Fax: 44-208-816-2564; E-mail: aogarra{at}nimr.mrc.ac.uk or andre.boonstra{at}nimr.mrc.ac.uk

Distinct dendritic cell (DC) subsets have been suggested to be preprogrammed to direct either T helper cell (Th) type 1 or Th2 development, although more recently different pathogen products or stimuli have been shown to render these DCs more flexible. It is still unclear how distinct mouse DC subsets cultured from bone marrow precursors, blood, or their lymphoid tissue counterparts direct Th differentiation. We show that mouse myeloid and plasmacytoid precursor DCs (pDCs) cultured from bone marrow precursors and ex vivo splenic DC subsets can induce the development of both Th1 and Th2 effector cells depending on the dose of antigen. In general, high antigen doses induced Th1 cell development whereas low antigen doses induced Th2 cell development. Both cultured and ex vivo splenic plasmacytoid-derived DCs enhanced CD4⁺ T cell proliferation and induced strong Th1 cell development when activated with the Toll-like receptor (TLR)9 ligand CpG, and not with the TLR4 ligand lipopolysaccharide (LPS). The responsiveness of plasmacytoid pDCs to CpG correlated with high TLR9 expression similarly to human plasmacytoid pDCs. Conversely, myeloid DCs generated with granulocyte/macrophage colony-stimulating factor enhanced Th1 cell development when stimulated with LPS as a result of their high level of TLR4 expression. Polarized Th1 responses resulting from high antigen dose were not additionally enhanced by stimulation of DCs by TLR ligands. Thus, the net effect of antigen dose, the state of maturation of the DCs together with the stimulation of DCs by pathogen-derived products, will determine whether a Th1 or Th2 response develops.

Key Words: dendritic cell • Th1 • Th2 • TLR • cytokines

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Vultaggio, A., Nencini, F., Fitch, P. M., Fili, L., Maggi, L., Fanti, P., deVries, A., Beccastrini, E., Palandri, F., Manuelli, C., Bani, D., Giudizi, M. G., Guarna, A., Annunziato, F., Romagnani, S., Maggi, E., Howie, S. E. M., Parronchi, P. (2009). Modified Adenine (9-Benzyl-2-Butoxy-8-Hydroxyadenine) Redirects Th2-Mediated Murine Lung Inflammation by Triggering TLR7. J. Immunol. 182: 880-889 [Abstract] [Full Text]  
• Nakasaki, T., Tanaka, T., Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., Miyasaka, M. (2008). Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions. Am. J. Pathol. 173: 1566-1576 [Abstract] [Full Text]  
• Mouries, J., Moron, G., Schlecht, G., Escriou, N., Dadaglio, G., Leclerc, C. (2008). Plasmacytoid dendritic cells efficiently cross-prime naive T cells in vivo after TLR activation. Blood 112: 3713-3722 [Abstract] [Full Text]  
• Nishimoto, K. P., Laust, A. K., Nelson, E. L. (2008). A Human Dendritic Cell Subset Receptive to the Venezuelan Equine Encephalitis Virus-Derived Replicon Particle Constitutively Expresses IL-32. J. Immunol. 181: 4010-4018 [Abstract] [Full Text]  
• Nagashima, O., Harada, N., Usui, Y., Yamazaki, T., Yagita, H., Okumura, K., Takahashi, K., Akiba, H. (2008). B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma. J. Immunol. 181: 4062-4071 [Abstract] [Full Text]  
• Bochtler, P., Kroger, A., Schirmbeck, R., Reimann, J. (2008). Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells. J. Immunol. 181: 1633-1643 [Abstract] [Full Text]  
• Lamhamedi-Cherradi, S.-E., Martin, R. E., Ito, T., Kheradmand, F., Corry, D. B., Liu, Y.-J., Moyle, M. (2008). Fungal Proteases Induce Th2 Polarization through Limited Dendritic Cell Maturation and Reduced Production of IL-12. J. Immunol. 180: 6000-6009 [Abstract] [Full Text]  
• Pepper, M., Dzierszinski, F., Wilson, E., Tait, E., Fang, Q., Yarovinsky, F., Laufer, T. M., Roos, D., Hunter, C. A. (2008). Plasmacytoid Dendritic Cells Are Activated by Toxoplasma gondii to Present Antigen and Produce Cytokines. J. Immunol. 180: 6229-6236 [Abstract] [Full Text]  
• Wiethe, C., Debus, A., Mohrs, M., Steinkasserer, A., Lutz, M., Gessner, A. (2008). Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection. J. Immunol. 180: 4371-4381 [Abstract] [Full Text]  
• Macedo, G. C., Magnani, D. M., Carvalho, N. B., Bruna-Romero, O., Gazzinelli, R. T., Oliveira, S. C. (2008). Central Role of MyD88-Dependent Dendritic Cell Maturation and Proinflammatory Cytokine Production to Control Brucella abortus Infection. J. Immunol. 180: 1080-1087 [Abstract] [Full Text]  
• Fransen, F., Boog, C. J., van Putten, J. P., van der Ley, P. (2007). Agonists of Toll-Like Receptors 3, 4, 7, and 9 Are Candidates for Use as Adjuvants in an Outer Membrane Vaccine against Neisseria meningitidis Serogroup B. Infect. Immun. 75: 5939-5946 [Abstract] [Full Text]  
• Porter, M., Karp, M., Killedar, S., Bauer, S. M., Guo, J., Williams, D., Breysse, P., Georas, S. N., Williams, M. A. (2007). Diesel-Enriched Particulate Matter Functionally Activates Human Dendritic Cells. Am. J. Respir. Cell Mol. Bio. 37: 706-719 [Abstract] [Full Text]  
• Greenberg, S. A. (2007). Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications. Neurology 69: 2008-2019 [Abstract] [Full Text]  
• Ramos, H. J., Davis, A. M., George, T. C., Farrar, J. D. (2007). IFN-{alpha} Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression. J. Immunol. 179: 3792-3803 [Abstract] [Full Text]  
• Star, L., Nieuwland, M. G. B., Kemp, B., Parmentier, H. K. (2007). Effect of Single or Combined Climatic and Hygienic Stress on Natural and Specific Humoral Immune Competence in Four Layer Lines. Poult. Sci. 86: 1894-1903 [Abstract] [Full Text]  
• Sapoznikov, A., Fischer, J. A.A., Zaft, T., Krauthgamer, R., Dzionek, A., Jung, S. (2007). Organ-dependent in vivo priming of naive CD4+,but not CD8+,T cells by plasmacytoid dendritic cells. JEM 204: 1923-1933 [Abstract] [Full Text]  
• Skokos, D., Nussenzweig, M. C. (2007). CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. JEM 204: 1525-1531 [Abstract] [Full Text]  
• Lamb, R. J., Capocasale, R. J., Duffy, K. E., Sarisky, R. T., Mbow, M. L. (2007). Identification and Characterization of Novel Bone Marrow Myeloid DEC205+Gr-1+ Cell Subsets That Differentially Express Chemokine and TLRs. J. Immunol. 178: 7833-7839 [Abstract] [Full Text]  
• Chen, L., Calomeni, E., Wen, J., Ozato, K., Shen, R., Gao, J.-X. (2007). Natural killer dendritic cells are an intermediate of developing dendritic cells. J. Leukoc. Biol. 81: 1422-1433 [Abstract] [Full Text]  
• Severa, M., Remoli, M. E., Giacomini, E., Annibali, V., Gafa, V., Lande, R., Tomai, M., Salvetti, M., Coccia, E. M. (2007). Sensitization to TLR7 Agonist in IFN-beta-Preactivated Dendritic Cells. J. Immunol. 178: 6208-6216 [Abstract] [Full Text]  
• Winkler, P., Ghadimi, D., Schrezenmeir, J., Kraehenbuhl, J.-P. (2007). Molecular and Cellular Basis of Microflora-Host Interactions. J. Nutr. 137: 756S-772S [Abstract] [Full Text]  
• Shamshiev, A. T., Ampenberger, F., Ernst, B., Rohrer, L., Marsland, B. J., Kopf, M. (2007). Dyslipidemia inhibits Toll-like receptor-induced activation of CD8{alpha}-negative dendritic cells and protective Th1 type immunity. JEM 204: 441-452 [Abstract] [Full Text]  
• Stober, C. B., Lange, U. G., Roberts, M. T. M., Alcami, A., Blackwell, J. M. (2007). Heterologous Priming-Boosting with DNA and Modified Vaccinia Virus Ankara Expressing Tryparedoxin Peroxidase Promotes Long-Term Memory against Leishmania major in Susceptible BALB/c Mice. Infect. Immun. 75: 852-860 [Abstract] [Full Text]  
• Sun, J., Pearce, E. J. (2007). Suppression of Early IL-4 Production Underlies the Failure of CD4 T Cells Activated by TLR-Stimulated Dendritic Cells to Differentiate into Th2 Cells. J. Immunol. 178: 1635-1644 [Abstract] [Full Text]  
• Brogdon, J. L., Xu, Y., Szabo, S. J., An, S., Buxton, F., Cohen, D., Huang, Q. (2007). Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood 109: 1123-1130 [Abstract] [Full Text]  
• Popovic, P. J., DeMarco, R., Lotze, M. T., Winikoff, S. E., Bartlett, D. L., Krieg, A. M., Guo, Z. S., Brown, C. K., Tracey, K. J., Zeh, H. J. III (2006). High Mobility Group B1 Protein Suppresses the Human Plasmacytoid Dendritic Cell Response to TLR9 Agonists. J. Immunol. 177: 8701-8707 [Abstract] [Full Text]  
• Gabriele, L., Fragale, A., Borghi, P., Sestili, P., Stellacci, E., Venditti, M., Schiavoni, G., Sanchez, M., Belardelli, F., Battistini, A. (2006). IRF-1 deficiency skews the differentiation of dendritic cells toward plasmacytoid and tolerogenic features. J. Leukoc. Biol. 80: 1500-1511 [Abstract] [Full Text]  
• Hoene, V., Peiser, M., Wanner, R. (2006). Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19. J. Leukoc. Biol. 80: 1328-1336 [Abstract] [Full Text]  
• Boonstra, A., Rajsbaum, R., Holman, M., Marques, R., Asselin-Paturel, C., Pereira, J. P., Bates, E. E. M., Akira, S., Vieira, P., Liu, Y.-J., Trinchieri, G., O'Garra, A. (2006). Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals. J. Immunol. 177: 7551-7558 [Abstract] [Full Text]  
• Masten, B. J., Olson, G. K., Tarleton, C. A., Rund, C., Schuyler, M., Mehran, R., Archibeque, T., Lipscomb, M. F. (2006). Characterization of Myeloid and Plasmacytoid Dendritic Cells in Human Lung. J. Immunol. 177: 7784-7793 [Abstract] [Full Text]  
• Wang, H., Peters, N., Schwarze, J. (2006). Plasmacytoid Dendritic Cells Limit Viral Replication, Pulmonary Inflammation, and Airway Hyperresponsiveness in Respiratory Syncytial Virus Infection. J. Immunol. 177: 6263-6270 [Abstract] [Full Text]  
• Reinhardt, R. L., Hong, S., Kang, S.-J., Wang, Z.-e., Locksley, R. M. (2006). Visualization of IL-12/23p40 In Vivo Reveals Immunostimulatory Dendritic Cell Migrants that Promote Th1 Differentiation. J. Immunol. 177: 1618-1627 [Abstract] [Full Text]  
• Montoya, C. J., Jie, H.-B., Al-Harthi, L., Mulder, C., Patino, P. J., Rugeles, M. T., Krieg, A. M., Landay, A. L., Wilson, S. B. (2006). Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells. J. Immunol. 177: 1028-1039 [Abstract] [Full Text]  
• Rutella, S., Bonanno, G., Procoli, A., Mariotti, A., de Ritis, D. G., Curti, A., Danese, S., Pessina, G., Pandolfi, S., Natoni, F., Di Febo, A., Scambia, G., Manfredini, R., Salati, S., Ferrari, S., Pierelli, L., Leone, G., Lemoli, R. M. (2006). Hepatocyte growth factor favors monocyte differentiation into regulatory interleukin (IL)-10++IL-12low/neg accessory cells with dendritic-cell features. Blood 108: 218-227 [Abstract] [Full Text]  
• Sponaas, A.-M., Cadman, E. T., Voisine, C., Harrison, V., Boonstra, A., O'Garra, A., Langhorne, J. (2006). Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells. JEM 203: 1427-1433 [Abstract] [Full Text]  
• Wen, H., Hogaboam, C. M., Gauldie, J., Kunkel, S. L. (2006). Severe Sepsis Exacerbates Cell-Mediated Immunity in the Lung Due to an Altered Dendritic Cell Cytokine Profile. Am. J. Pathol. 168: 1940-1950 [Abstract] [Full Text]  
• Greene, J. A., DeVecchio, J. L., Gould, M. P., Auletta, J. J., Heinzel, F. P. (2006). In vivo and In vitro Regulation of Type I IFN Synthesis by Synergistic Effects of CD40 and Type II IFN. J. Immunol. 176: 5995-6003 [Abstract] [Full Text]  
• Zhang, J., Raper, A., Sugita, N., Hingorani, R., Salio, M., Palmowski, M. J., Cerundolo, V., Crocker, P. R. (2006). Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Blood 107: 3600-3608 [Abstract] [Full Text]  
• Christmas, P., Tolentino, K., Primo, V., Berry, K. Z., Murphy, R. C., Chen, M., Lee, D. M., Soberman, R. J. (2006). Cytochrome P-450 4F18 Is the Leukotriene B4 {omega}-1/{omega}-2 Hydroxylase in Mouse Polymorphonuclear Leukocytes: IDENTIFICATION AS THE FUNCTIONAL ORTHOLOGUE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE CYP4F3A IN THE DOWN-REGULATION OF RESPONSES TO LTB4. J. Biol. Chem. 281: 7189-7196 [Abstract] [Full Text]  
• Chen, X., Reed-Loisel, L. M., Karlsson, L., Jensen, P. E. (2006). H2-O Expression in Primary Dendritic Cells. J. Immunol. 176: 3548-3556 [Abstract] [Full Text]  
• Curtis, J. L. (2005). Cell-mediated Adaptive Immune Defense of the Lungs. Proc Am Thorac Soc 2: 412-416 [Abstract] [Full Text]  
• Guo, Z., Garg, S., Hill, K. M., Jayashankar, L., Mooney, M. R., Hoelscher, M., Katz, J. M., Boss, J. M., Sambhara, S. (2005). A Distal Regulatory Region Is Required for Constitutive and IFN-{beta}-Induced Expression of Murine TLR9 Gene. J. Immunol. 175: 7407-7418 [Abstract] [Full Text]  
• Huang, X., Barrett, R. P., McClellan, S. A., Hazlett, L. D. (2005). Silencing Toll-like Receptor-9 in Pseudomonas aeruginosa Keratitis. IOVS 46: 4209-4216 [Abstract] [Full Text]  
• Suto, A., Nakajima, H., Tokumasa, N., Takatori, H., Kagami, S.-i., Suzuki, K., Iwamoto, I. (2005). Murine Plasmacytoid Dendritic Cells Produce IFN-{gamma} upon IL-4 Stimulation. J. Immunol. 175: 5681-5689 [Abstract] [Full Text]  
• Wille-Reece, U., Flynn, B. J., Lore, K., Koup, R. A., Kedl, R. M., Mattapallil, J. J., Weiss, W. R., Roederer, M., Seder, R. A. (2005). HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates. Proc. Natl. Acad. Sci. USA 102: 15190-15194 [Abstract] [Full Text]  
• Tsujimoto, H., Uchida, T., Efron, P. A., Scumpia, P. O., Verma, A., Matsumoto, T., Tschoeke, S. K., Ungaro, R. F., Ono, S., Seki, S., Clare-Salzler, M. J., Baker, H. V., Mochizuki, H., Ramphal, R., Moldawer, L. L. (2005). Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J. Leukoc. Biol. 78: 888-897 [Abstract] [Full Text]  
• Bendriss-Vermare, N., Burg, S., Kanzler, H., Chaperot, L., Duhen, T., de Bouteiller, O., D'agostini, M., Bridon, J.-M., Durand, I., Sederstrom, J. M., Chen, W., Plumas, J., Jacob, M.-C., Liu, Y.-J., Garrone, P., Trinchieri, G., Caux, C., Briere, F. (2005). Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. J. Leukoc. Biol. 78: 954-966 [Abstract] [Full Text]  
• Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A., Antel, J. P. (2005). TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes. J. Immunol. 175: 4320-4330 [Abstract] [Full Text]  
• Happel, K. I., Dubin, P. J., Zheng, M., Ghilardi, N., Lockhart, C., Quinton, L. J., Odden, A. R., Shellito, J. E., Bagby, G. J., Nelson, S., Kolls, J. K. (2005). Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. JEM 202: 761-769 [Abstract] [Full Text]  
• Feili-Hariri, M., Falkner, D. H., Morel, P. A. (2005). Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy. J. Leukoc. Biol. 78: 656-664 [Abstract] [Full Text]  
• Chu, C.-L., Lowell, C. A. (2005). The Lyn Tyrosine Kinase Differentially Regulates Dendritic Cell Generation and Maturation. J. Immunol. 175: 2880-2889 [Abstract] [Full Text]  
• Vermaelen, K., Pauwels, R. (2005). Pulmonary Dendritic Cells. Am. J. Respir. Crit. Care Med. 172: 530-551 [Abstract] [Full Text]  
• Angelov, G. S., Tomkowiak, M., Marcais, A., Leverrier, Y., Marvel, J. (2005). Flt3 Ligand-Generated Murine Plasmacytoid and Conventional Dendritic Cells Differ in Their Capacity to Prime Naive CD8 T Cells and to Generate Memory Cells In Vivo. J. Immunol. 175: 189-195 [Abstract] [Full Text]  
• Riedl, M. A., Landaw, E. M., Saxon, A., Diaz-Sanchez, D. (2005). Initial High-Dose Nasal Allergen Exposure Prevents Allergic Sensitization to a Neoantigen. J. Immunol. 174: 7440-7445 [Abstract] [Full Text]  
• Pelayo, R., Hirose, J., Huang, J., Garrett, K. P., Delogu, A., Busslinger, M., Kincade, P. W. (2005). Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow. Blood 105: 4407-4415 [Abstract] [Full Text]  
• Yasuda, K., Yu, P., Kirschning, C. J., Schlatter, B., Schmitz, F., Heit, A., Bauer, S., Hochrein, H., Wagner, H. (2005). Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways. J. Immunol. 174: 6129-6136 [Abstract] [Full Text]  
• Prakash, A., Smith, E., Lee, C.-k., Levy, D. E. (2005). Tissue-specific Positive Feedback Requirements for Production of Type I Interferon following Virus Infection. J. Biol. Chem. 280: 18651-18657 [Abstract] [Full Text]  
• Weatherill, A. R., Lee, J. Y., Zhao, L., Lemay, D. G., Youn, H. S., Hwang, D. H. (2005). Saturated and Polyunsaturated Fatty Acids Reciprocally Modulate Dendritic Cell Functions Mediated through TLR4. J. Immunol. 174: 5390-5397 [Abstract] [Full Text]  
• Asselin-Paturel, C., Brizard, G., Chemin, K., Boonstra, A., O'Garra, A., Vicari, A., Trinchieri, G. (2005). Type I interferon dependence of plasmacytoid dendritic cell activation and migration. JEM 201: 1157-1167 [Abstract] [Full Text]  
• Getz, G. S. (2005). Bridging the innate and adaptive immune systems. J. Lipid Res. 46: 619-622 [Full Text]  
• Suzuki, K., Suda, T., Naito, T., Ide, K., Chida, K., Nakamura, H. (2005). Impaired Toll-like Receptor 9 Expression in Alveolar Macrophages with No Sensitivity to CpG DNA. Am. J. Respir. Crit. Care Med. 171: 707-713 [Abstract] [Full Text]  
• Pulendran, B. (2005). Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors. J. Immunol. 174: 2457-2465 [Abstract] [Full Text]  
• De Creus, A., Abe, M., Lau, A. H., Hackstein, H., Raimondi, G., Thomson, A. W. (2005). Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin. J. Immunol. 174: 2037-2045 [Abstract] [Full Text]  
• Fugier-Vivier, I. J., Rezzoug, F., Huang, Y., Graul-Layman, A. J., Schanie, C. L., Xu, H., Chilton, P. M., Ildstad, S. T. (2005). Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. JEM 201: 373-383 [Abstract] [Full Text]  
• Sanchez-Guajardo, V., Borghans, J. A. M., Marquez, M.-E., Garcia, S., Freitas, A. A. (2005). Different Competitive Capacities of Stat4- and Stat6-Deficient CD4+ T Cells during Lymphophenia-Driven Proliferation. J. Immunol. 174: 1178-1187 [Abstract] [Full Text]  
• Visser, L., Jan de Heer, H., Boven, L. A., van Riel, D., van Meurs, M., Melief, M.-J., Zahringer, U., van Strijp, J., Lambrecht, B. N., Nieuwenhuis, E. E., Laman, J. D. (2005). Proinflammatory Bacterial Peptidoglycan as a Cofactor for the Development of Central Nervous System Autoimmune Disease. J. Immunol. 174: 808-816 [Abstract] [Full Text]  
• Oriss, T. B., Ostroukhova, M., Seguin-Devaux, C., Dixon-McCarthy, B., Stolz, D. B., Watkins, S. C., Pillemer, B., Ray, P., Ray, A. (2005). Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation and Tolerance. J. Immunol. 174: 854-863 [Abstract] [Full Text]  
• Jenkins, S. J., Mountford, A. P. (2005). Dendritic Cells Activated with Products Released by Schistosome Larvae Drive Th2-Type Immune Responses, Which Can Be Inhibited by Manipulation of CD40 Costimulation. Infect. Immun. 73: 395-402 [Abstract] [Full Text]  
• Schlecht, G., Garcia, S., Escriou, N., Freitas, A. A., Leclerc, C., Dadaglio, G. (2004). Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 104: 1808-1815 [Abstract] [Full Text]  
• Rivas-Carvalho, A., Meraz-Rios, M. A., Santos-Argumedo, L., Bajana, S., Soldevila, G., Moreno-Garcia, M. E., Sanchez-Torres, C. (2004). CD16+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines. Int Immunol 16: 1251-1263 [Abstract] [Full Text]  
• Jankovic, D., Kullberg, M. C., Caspar, P., Sher, A. (2004). Parasite-Induced Th2 Polarization Is Associated with Down-Regulated Dendritic Cell Responsiveness to Th1 Stimuli and a Transient Delay in T Lymphocyte Cycling. J. Immunol. 173: 2419-2427 [Abstract] [Full Text]  
• Whitsett, J. A., Bachurski, C. J., Barnes, K. C., Bunn, P. A. Jr., Case, L. M., Cook, D. N., Crooks, D., Duncan, M. W., Dwyer-Nield, L., Elston, R. C., Fessler, M. B., Franklin, W. A., Friedman, N., Garcia, J. G. N., Geraci, M. W., Glasgow, C., Glasser, S. W., Hardie, W. D., Henning, L. M., Johnson, G. L., Kawkitinarong, K., Keith, R. L., Korfhagen, T. R., Leikauf, G. D., Liggett, S. B., Malcolm, K. C., Malkinson, A. M., Mariani, T. J., McDowell, S. A., McGraw, D. W., Medvedovic, M., Moss, J., Nogee, L. M., Nonas, S., Pacheco-Rodriguez, G., Palmer, L. J., Peters, D. G., Prows, D. R., Redline, S., Regev, A., Sartor, M. A., Schwartz, D. A., Silverman, E. K., Steagall, W. K., Stearman, R. S., Taveira-DaSilva, A., Tichelaar, J. W., Tomlinson, C. R., Tsukada, K., Weaver, T. E., Wert, S. E., Wesselkamper, S. C., Worthen, G. S., Xu, Y., Zerbe, L., Zhang, Y., Zhang, Y., Choi, A. M. K., Kaminski, N. (2004). Functional Genomics of Lung Disease. Am. J. Respir. Cell Mol. Bio. 31: S1-S81 [Full Text]  
• de Heer, H. J., Hammad, H., Soullie, T., Hijdra, D., Vos, N., Willart, M. A.M., Hoogsteden, H. C., Lambrecht, B. N. (2004). Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen. JEM 200: 89-98 [Abstract] [Full Text]  
• Hubert, F.-X., Voisine, C., Louvet, C., Heslan, M., Josien, R. (2004). Rat Plasmacytoid Dendritic Cells Are an Abundant Subset of MHC Class II+ CD4+CD11b-OX62- and Type I IFN-Producing Cells That Exhibit Selective Expression of Toll-Like Receptors 7 and 9 and Strong Responsiveness to CpG. J. Immunol. 172: 7485-7494 [Abstract] [Full Text]  
• Uzonna, J. E., Joyce, K. L., Scott, P. (2004). Low Dose Leishmania major Promotes a Transient T Helper Cell Type 2 Response That Is Down-regulated by Interferon {gamma}-producing CD8+ T Cells. JEM 199: 1559-1566 [Abstract] [Full Text]  
• Didierlaurent, A., Ferrero, I., Otten, L. A., Dubois, B., Reinhardt, M., Carlsen, H., Blomhoff, R., Akira, S., Kraehenbuhl, J.-P., Sirard, J.-C. (2004). Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response. J. Immunol. 172: 6922-6930 [Abstract] [Full Text]  
• Blasius, A., Vermi, W., Krug, A., Facchetti, F., Cella, M., Colonna, M. (2004). A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood 103: 4201-4206 [Abstract] [Full Text]  
• Kollmann, T. R., Way, S. S., Harowicz, H. L., Hajjar, A. M., Wilson, C. B. (2004). Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells. Blood 103: 4240-4242 [Abstract] [Full Text]  
• Fonteneau, J.-F., Larsson, M., Beignon, A.-S., McKenna, K., Dasilva, I., Amara, A., Liu, Y.-J., Lifson, J. D., Littman, D. R., Bhardwaj, N. (2004). Human Immunodeficiency Virus Type 1 Activates Plasmacytoid Dendritic Cells and Concomitantly Induces the Bystander Maturation of Myeloid Dendritic Cells. J. Virol. 78: 5223-5232 [Abstract] [Full Text]  
• Ramirez-Pineda, J. R., Frohlich, A., Berberich, C., Moll, H. (2004). Dendritic Cells (DC) Activated by CpG DNA Ex Vivo Are Potent Inducers of Host Resistance to an Intracellular Pathogen That Is Independent of IL-12 Derived from the Immunizing DC. J. Immunol. 172: 6281-6289 [Abstract] [Full Text]  
• Lavelle, E. C., Jarnicki, A., McNeela, E., Armstrong, M. E., Higgins, S. C., Leavy, O., Mills, K. H. G. (2004). Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J. Leukoc. Biol. 75: 756-763 [Abstract] [Full Text]  
• Mazzoni, A., Segal, D. M. (2004). Controlling the Toll road to dendritic cell polarization. J. Leukoc. Biol. 75: 721-730 [Abstract] [Full Text]  
• Dillon, S., Agrawal, A., Van Dyke, T., Landreth, G., McCauley, L., Koh, A., Maliszewski, C., Akira, S., Pulendran, B. (2004). A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells. J. Immunol. 172: 4733-4743 [Abstract] [Full Text]  
• Yasumi, T., Katamura, K., Yoshioka, T., Meguro, T.-a., Nishikomori, R., Heike, T., Inobe, M., Kon, S., Uede, T., Nakahata, T. (2004). Differential Requirement for the CD40-CD154 Costimulatory Pathway during Th Cell Priming by CD8{alpha}+ and CD8{alpha}− Murine Dendritic Cell Subsets. J. Immunol. 172: 4826-4833 [Abstract] [Full Text]  
• Lund, J. M., Alexopoulou, L., Sato, A., Karow, M., Adams, N. C., Gale, N. W., Iwasaki, A., Flavell, R. A. (2004). Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 101: 5598-5603 [Abstract] [Full Text]  
• Baldwin, T., Henri, S., Curtis, J., O'Keeffe, M., Vremec, D., Shortman, K., Handman, E. (2004). Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes. Infect. Immun. 72: 1991-2001 [Abstract] [Full Text]  
• Masten, B. J., Olson, G. K., Kusewitt, D. F., Lipscomb, M. F. (2004). Flt3 Ligand Preferentially Increases the Number of Functionally Active Myeloid Dendritic Cells in the Lungs of Mice. J. Immunol. 172: 4077-4083 [Abstract] [Full Text]  
• Candon, S., McHugh, R. S., Foucras, G., Natarajan, K., Shevach, E. M., Margulies, D. H. (2004). Spontaneous Organ-Specific Th2-Mediated Autoimmunity in TCR Transgenic Mice. J. Immunol. 172: 2917-2924 [Abstract] [Full Text]  
• Salio, M., Palmowski, M. J., Atzberger, A., Hermans, I. F., Cerundolo, V. (2004). CpG-matured Murine Plasmacytoid Dendritic Cells Are Capable of In Vivo Priming of Functional CD8 T Cell Responses to Endogenous but Not Exogenous Antigens. JEM 199: 567-579 [Abstract] [Full Text]  
• Cervi, L., MacDonald, A. S., Kane, C., Dzierszinski, F., Pearce, E. J. (2004). Cutting Edge: Dendritic Cells Copulsed with Microbial and Helminth Antigens Undergo Modified Maturation, Segregate the Antigens to Distinct Intracellular Compartments, and Concurrently Induce Microbe-Specific Th1 and Helminth-Specific Th2 Responses. J. Immunol. 172: 2016-2020 [Abstract] [Full Text]  
• Krug, A., Luker, G. D., Barchet, W., Leib, D. A., Akira, S., Colonna, M. (2004). Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103: 1433-1437 [Abstract] [Full Text]  
• Wagner, M., Poeck, H., Jahrsdoerfer, B., Rothenfusser, S., Prell, D., Bohle, B., Tuma, E., Giese, T., Ellwart, J. W., Endres, S., Hartmann, G. (2004). IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA. J. Immunol. 172: 954-963 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS