The Journal of Experimental Medicine
StemCell Technologies
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Published 1 July 2002. doi:10.1084/jem.20012094
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© Rockefeller University Press, 0022-1007/2002/7/135/ $5.00
The Journal of Experimental Medicine, Volume 196, Number 1, July 1, 2002 135-140

Brief Definitive Report

 Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

Philip L. Cohen1, Roberto Caricchio1, Valsamma Abraham1, Todd D. Camenisch2, J. Charles Jennette3, Robert A.S. Roubey4, H. Shelton Earp4, Glenn Matsushima5 and Elizabeth A. Reap6

1 Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104
2 Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ 85259
3 Department of Pathology, University of North Carolina, Chapel Hill, NC 27599
4 Department of Medicine, University of North Carolina, Chapel Hill, NC 27599
5 Department of Microbiology/Immunology, University of North Carolina, Chapel Hill, NC 27599
6 AlphaVax, Durham, NC 27709

Address correspondence to P.L. Cohen, Department of Medicine, Division of Rheumatology, University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA 19104. Phone: 215-573-2956; Fax: 215-573-7599; E-mail: philipco{at}mail.med.upenn.edu

Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macro-phage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer–deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity.

Key Words: autoimmunity • Lupus Erythematosus, systemic • phagocytosis • apoptosis • macrophages


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